Article
Sequential Immunization Elicits Broadly Neutralizing
Anti-HIV-1 Antibodies in Ig Knockin Mice
Graphical Abstract
Highlights
d Immunization elicits anti-HIV-1 broadly neutralizing
antibodies in knockin mice
d ELISA-guided sequential immunization induces high levels
of somatic mutation
d Mouse antibodies elicited by sequential immunization
resemble human antibodies
Authors
Amelia Escolano, Jon M. Steichen,
Pia Dosenovic, ..., Dennis R. Burton,
William R. Schief, Michel C. Nussenzweig
Correspondence
[email protected] (W.R.S.),
[email protected] (M.C.N.)
In Brief
Generation of HIV broadly neutralizing
antibodies—a major goal in vaccine
research—can be achieved through
sequential immunization with HIV
envelope glycoproteins designed to
engage PGT121 antibody precursors and
their intermediates.
Escolano et al., 2016, Cell 166 , 1445–1458
September 8, 2016ª2016 Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.07.030