Figure7. AlignmentoftheMonoclonalIGHandIGKtotheInferredGermlineandMatureMutatedPGT121,PGT122,PGT123,and10-1074bNAbs
(A) Alignment of IGH sequences from the monoclonal antibodies inFigure 6.
(B) Alignment of IGK sequences from monoclonal antibodies inFigure 6. The name of the antibody is indicated. Colors represent different amino acids. Dots
represent identity to the germline reference sequence. Color coded asterisks next to the antibody name indicate neutralizing antibodies and their neutralization
score (seeSTAR Methods). Red indicates higher neutralization score. Amino acid substitutions that were previously identified as critical for binding to Env and
neutralization of HIV-1 isolates are enclosed in a red rectangle. Antibody regions are indicated in gray. FR, framework region; CDR, complementarity determining
region. Amino acid position is indicated with numbers on top of each reference sequence.
Cell 166 , 1445–1458, September 8, 2016 1455