Article
gdT Cells Support Pancreatic Oncogenesis by
Restrainingab T Cell Activation
Graphical Abstract
Highlights
d gdT cells are highly prevalent in human pancreatic
carcinoma
d Deletion or interruption ofgdT cell recruitment is protective in
pancreatic cancer
d Pancreatic cancer infiltratinggdT cells express high levels of
checkpoint ligands
d gdT cells disableabT cell activation via checkpoint receptor
ligation
Authors
Donnele Daley,
Constantinos Pantelis Zambirinis,
Lena Seifert, ..., Dafna Bar-Sagi,
Cristina Hajdu, George Miller
Correspondence
[email protected]
In Brief
gdT cells are key regulators of effector
T cell activation in pancreatic cancer and
a new target for cancer immunotherapy.
Daley et al., 2016, Cell 166 , 1485โ1499
September 8, 2016ยช2016 Elsevier Inc.
http://dx.doi.org/10.1016/j.cell.2016.07.046