Figure 3. Caloric Supplementation and Glucose Utilization Is Required for Surviving Influenza Infection
(A) Food consumption after infection with 450 plaque forming units (PFUs) of influenza strain A/WSN/33.
(B and C) Survival after infection with 800 PFUs of influenza virus. Mice were gavaged with food, glucose, or PBS vehicle. Mice gavaged with food were also
injected with IP PBS (food) or 2DG (food+2DG). PBS versus food p = 0.0047; PBS versus glucose p = 0.1058; food versus food+2DG p = 0.0001; PBS versus
food+2DG p = 0.0256. n = 10/group. (B) is a subset of (C), separated for clarity (the same PBS-treated and food-treated groups are shown in B and C).
(D) Survival after infection with 375 PFUs of influenza virus and treatment with IP PBS or 2DG. p < 0.0001; n = 10/group.
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