Cell - 8 September 2016

Article

Nuclear Pore Permeabilization Is a Convergent

Signaling Event in Effector-Triggered Immunity

Graphical Abstract

Highlights

d CPR5 is a component of the nuclear pore complex (NPC)

d CPR5 regulates nuclear transport through the selective

barrier of the NPC

d The CPR5 homomer is disrupted upon induction of effector-

triggered immunity (ETI)

d Conformational change in CPR5 leads to CKI release and

NPC permeabilization for ETI

Authors

Yangnan Gu, Sophia G. Zebell,

Zizhen Liang, Shui Wang,

Byung-Ho Kang, Xinnian Dong

Correspondence

[email protected]

In Brief

Rather than being a passive conduit, the

nuclear pore complex, in response to

immune signals, undergoes a

conformational switch to reconfigure the

selective barrier and promote stress

signaling.

Data Resources

GSE72742

GSE72743

Gu et al., 2016, Cell 166 , 1526–1538

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.07.042