Cell - 8 September 2016

Article

Lipid Biosynthesis Coordinates a Mitochondrial-to-

Cytosolic Stress Response

Graphical Abstract

Highlights

d Distinct disruption of mitochondrial proteostasis activates

the MCSR

d Fatty acid biosynthesis is required for the MCSR

d MCSR requires the stress-responsive transcription factors

dve-1andhsf-1

d MCSR ameliorates polyQ-mediated toxicity and can be

targeted with small molecules

Authors

Hyun-Eui Kim, Ana Rodrigues Grant,

Milos S. Simic, ..., Erik Kapernick,

Suzanne Wolff, Andrew Dillin

Correspondence

[email protected]

In Brief

How is mitochondrial stress signaled to

other cellular compartments?

Kim et al., 2016, Cell 166 , 1539–1552

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.08.027