Cell - 8 September 2016

(Amelia) #1

Kim, D., Ouyang, H., and Li, G.C. (1995). Heat shock protein hsp70 accelerates
the recovery of heat-shocked mammalian cells through its modulation of heat
shock transcription factor HSF1. Proc. Natl. Acad. Sci. USA 92 , 2126–2130.
Kirstein-Miles, J., and Morimoto, R.I. (2010).Caenorhabditis elegansas a
model system to study intercompartmental proteostasis: Interrelation of mito-
chondrial function, longevity, and neurodegenerative diseases. Dev. Dyn. 239 ,
1529–1538.
Lindquist, S. (1980). Varying patterns of protein synthesis in Drosophila during
heat shock: implications for regulation. Dev. Biol. 77 , 463–479.
Lindquist, S. (1981). Regulation of protein synthesis during heat shock. Nature
293 , 311–314.
Liu, Y., and Chang, A. (2008). Heat shock response relieves ER stress. EMBO
J. 27 , 1049–1059.
Liu, Y., Samuel, B.S., Breen, P.C., and Ruvkun, G. (2014). Caenorhabditis
elegans pathways that surveil and defend mitochondria. Nature 508 , 406–410.
Lu, Y.-W., and Claypool, S.M. (2015). Disorders of phospholipid metabolism:
an emerging class of mitochondrial disease due to defects in nuclear genes.
Front. Genet. 6 ,3.
Mao, J., DeMayo, F.J., Li, H., Abu-Elheiga, L., Gu, Z., Shaikenov, T.E., Kordari,
P., Chirala, S.S., Heird, W.C., and Wakil, S.J. (2006). Liver-specific deletion of
acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without
affecting glucose homeostasis. Proc. Natl. Acad. Sci. USA 103 , 8552–8557.
Mao, J., Yang, T., Gu, Z., Heird, W.C., Finegold, M.J., Lee, B., and Wakil, S.J.
(2009). aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes
growth retardation and reduced lipid accumulation in adipose tissues. Proc.
Natl. Acad. Sci. USA 106 , 17576–17581.
Mayer, M.P., and Bukau, B. (2005). Hsp70 chaperones: cellular functions and
molecular mechanism. Cell. Mol. Life Sci. 62 , 670–684.
Miller, M.J., Xuong, N.H., and Geiduschek, E.P. (1979). A response of protein
synthesis to temperature shift in the yeast Saccharomyces cerevisiae. Proc.
Natl. Acad. Sci. USA 76 , 5222–5225.
Morley, J.F., Brignull, H.R., Weyers, J.J., and Morimoto, R.I. (2002). The
threshold for polyglutamine-expansion protein aggregation and cellular
toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc.
Natl. Acad. Sci. USA 99 , 10417–10422.
Nishizawa, J., Nakai, A., Matsuda, K., Komeda, M., Ban, T., and Nagata, K.
(1999). Reactive oxygen species play an important role in the activation of
heat shock factor 1 in ischemic-reperfused heart. Circulation 99 , 934–941.
Okino, N., He, X., Gatt, S., Sandhoff, K., Ito, M., and Schuchman, E.H. (2003).
The reverse activity of human acid ceramidase. J. Biol. Chem. 278 , 29948–
29953.
Reis-Rodrigues, P., Czerwieniec, G., Peters, T.W., Evani, U.S., Alavez, S.,
Gaman, E.A., Vantipalli, M., Mooney, S.D., Gibson, B.W., Lithgow, G.J., and
Hughes, R.E. (2012). Proteomic analysis of age-dependent changes in protein
solubility identifies genes that modulate lifespan. Aging Cell 11 , 120–127.


Ritchie, M.E., Phipson, B., Wu, D., Hu, Y., Law, C.W., Shi, W., and Smyth, G.K.
(2015). limma powers differential expression analyses for RNA-sequencing
and microarray studies. Nucleic Acids Res. 43 , e47.
Ron, D., and Walter, P. (2007). Signal integration in the endoplasmic reticulum
unfolded protein response. Nat. Rev. Mol. Cell Biol. 8 , 519–529.
Sartor, M.A., Leikauf, G.D., and Medvedovic, M. (2009). LRpath: a logistic
regression approach for identifying enriched biological groups in gene expres-
sion data. Bioinformatics 25 , 211–217.
Senft, D., and Ronai, Z.A. (2015). UPR, autophagy, and mitochondria crosstalk
underlies the ER stress response. Trends Biochem. Sci. 40 , 141–148.
Steinkraus, K.A., Smith, E.D., Davis, C., Carr, D., Pendergrass, W.R., Sutphin,
G.L., Kennedy, B.K., and Kaeberlein, M. (2008). Dietary restriction suppresses
proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in
Caenorhabditis elegans. Aging Cell 7 , 394–404.
Supek,F., Bosnjak, M.,Skunca, N., and Smuc, T. (2011). REVIGO summarizes
and visualizes long lists of gene ontology terms. PLoS ONE 6 , e21800.
Tavaria, M., Gabriele, T., Kola, I., and Anderson, R.L. (1996). A hitchhiker’s
guide to the human Hsp70 family. Cell Stress Chaperones 1 , 23–28.
Thibault, G., Shui, G., Kim, W., McAlister, G.C., Ismail, N., Gygi, S.P., Wenk,
M.R., and Ng, D.T.W. (2012). The membrane stress response buffers lethal ef-
fects of lipid disequilibrium by reprogramming the protein homeostasis
network. Mol. Cell 48 , 16–27.
Vannuvel, K., Renard, P., Raes, M., and Arnould, T. (2013). Functional and
morphological impact of ER stress on mitochondria. J. Cell. Physiol. 228 ,
1802–1818.
Veatch, J.R., McMurray, M.A., Nelson, Z.W., and Gottschling, D.E. (2009).
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur
cluster defect. Cell 137 , 1247–1258.
Wang, M., Wey, S., Zhang, Y., Ye, R., and Lee, A.S. (2009). Role of the unfolded
protein response regulator GRP78/BiP in development, cancer, and neurolog-
ical disorders. Antioxid. Redox Signal. 11 , 2307–2316.
Wang, A.M., Miyata, Y., Klinedinst, S., Peng, H.-M., Chua, J.P., Komiyama, T.,
Li, X., Morishima, Y., Merry, D.E., Pratt, W.B., et al. (2013). Activation of Hsp70
reduces neurotoxicity by promoting polyglutamine protein degradation. Nat.
Chem. Biol. 9 , 112–118.
Westerheide, S.D., Anckar, J., Stevens, S.M., Jr., Sistonen, L., and Morimoto,
R.I. (2009). Stress-inducible regulation of heat shock factor 1 by the deacety-
lase SIRT1. Science 323 , 1063–1066.
Wiedemann, N., Frazier, A.E., and Pfanner, N. (2004). The protein import
machinery of mitochondria. J. Biol. Chem. 279 , 14473–14476.
Yang, Y., Cao, J., and Shi, Y. (2004). Identification and characterization of a
gene encoding human LPGAT1, an endoplasmic reticulum-associated lyso-
phosphatidylglycerol acyltransferase. J. Biol. Chem. 279 , 55866–55874.

1552 Cell 166 , 1539–1552, September 8, 2016

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