Cell - 8 September 2016

Article

Neuroendocrine Coordination of Mitochondrial

Stress Signaling and Proteostasis

Graphical Abstract

Highlights

d Across species, poly-glutamine repeat proteins bind to and

influence mitochondria

d PolyQ and other neuronal mitochondrial stress induce a cell-

non-autonomous UPRmt

d UPRmtpathway components are required for sensing PolyQ-

induced neuronal stress

d Serotonin synthesis and secretion are required for non-

autonomous UPRmtinduction

Authors

Kristen M. Berendzen, Jenni Durieux,

Li-Wa Shao, ..., Suzanne Wolff, Ying Liu,

Andrew Dillin

Correspondence

[email protected]

In Brief

How is mitochondrial stress in the

nervous system signaled to other

tissues?

Berendzen et al., 2016, Cell 166 , 1553–1563

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.08.042