Cell - 8 September 2016

Article

Dopamine Neuron-Specific Optogenetic Stimulation

in Rhesus Macaques

Graphical Abstract

Highlights

d Cell-type-specific promoter drives Cre-dependent ChR2

expression in monkey

d Optogenetically activated neurons had dopamine-like

features and reward responses

d Dopamine neurons respond strongly to cues predicting

optical stimulation

d Monkeys choose predicted optogenetic stimulation over no

predicted stimulation

Authors

William R. Stauffer, Armin Lak,

Aimei Yang, Melodie Borel, Ole Paulsen,

Edward S. Boyden, Wolfram Schultz

Correspondence

[email protected]

In Brief

Cell-type specific optogenetic

stimulation in Rhesus monkeys allows

manipulation of dopamine neurons to

demonstrate their role in reward-based

learning

Stauffer et al., 2016, Cell 166 , 1564–1571

September 8, 2016ª2016 The Authors. Published by Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.08.024