Despite these advances, we are just beginning to understand
the integral roles played by cellular metabolism in development
and diseases. In light of recent discoveries concerning the
interplay between intermediate metabolism and epigenetics,
the traditional view of metabolism as a developmental byproduct
has largely been refuted. To what extent cellular metabolism is
directly wired to cellular transitions associated with development
and reprograming warrants future investigations.
ACKNOWLEDGMENTS
We sincerely apologize to colleagues whose work has not been included in this
Review due to space limitations. We would like to thank all members of the
J.C.I.B. laboratory for their experimental and conceptual contributions, which
led to some of the ideas presented in this Review. We would like to thank May
Schwarz, David O’Keefe, and Peter Schwarz for critically reading the manu-
script. Work in the laboratory of J.C.I.B. was supported by the G. Harold
and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B.
Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, the Uni-
versidad Cato ́lica San Antonio de Murcia (UCAM), and Fundacion Pedro
Guillen.
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