Cell - 8 September 2016

Resource

Development of a Comprehensive Genotype-to-

Fitness Map of Adaptation-Driving Mutations in

Yeast

Graphical Abstract

Highlights

d High-throughput method to survey adaptive mutations in

laboratory evolution

d Isolation of thousands of independent single adaptive events

genome-wide

d Bulk fitness measurements and genotyping generates a

genotype-to-fitness map

d Large sample size allows sensitive detection of fitness

differences even within genes

Authors

Sandeep Venkataram, Barbara Dunn,

Yuping Li, ..., Daniel S. Fisher,

Gavin Sherlock, Dmitri A. Petrov

Correspondence

[email protected] (G.S.),

[email protected] (D.A.P.)

In Brief

How can the entire suite of adaptive

mutations that occur in an evolving

population be pinpointed and each of

their fitness effects measured?

Venkataram et al., 2016, Cell 167 , 1585–1596

September 8, 2016ª2016 Elsevier Inc.

http://dx.doi.org/10.1016/j.cell.2016.08.002