Cell - 8 September 2016

Figure S6. Distribution of Fitness Effects of the 418 Sequenced Clones Compared to that of the 4,800 Randomly Sampled Clones, Related to
Figures 1and 4
We intentionally over-enriched for high-fitness lineages among our 418 whole-genome sequenced clones (fitness distribution shown in blue) as compared to the
fitness distribution of the 4,800 sampled clones (red), in order to sample as many adaptation-driving mutations as possible.