Editorial Note
PPM1A Functions as a Smad
Phosphatase to Terminate
TGFbSignaling
Xia Lin,Xueyan Duan, Yao-Yun Liang, Ying Su, Katharine H. Wrighton, Jianyin Long, Min Hu, Candi M. Davis,
Jinrong Wang, F. Charles Brunicardi, Yigong Shi, Ye-Guang Chen, Anming Meng, and Xin-Hua Feng
*Corresponding authors
http://dx.doi.org/10.1016/j.cell.2016.08.062
(Cell 125 , 915–928; June 2, 2006)
We, the editors ofCell, published an Editorial Expression of Concern (http://dx.doi.org/10.1016/j.cell.2016.03.038) earlier this year
regarding issues raised about Figures 2F, 2H, and 3G of the above article. Dr. Yao-Yun Liang, who performed the experiments in
question, claimed to have manipulated his experiments to achieve pre-determined results. The corresponding author, Dr. Xin-Hua
Feng, refuted the claims of falsification. In the intervening time, two independent labs have carried out experiments attempting to
reproduce the data in question. This Editorial Note is to inform the community about the outcome of this process. Those two labs
have now completed their experiments, and their data largely confirm the central conclusions drawn from the original figures.
Although this does not resolve the conflicting claims, based on the information available to us at this time, we will take no further
action. We would like to thank the independent labs who invested significant time and effort in ensuring the accuracy of the scientific
record.
Cell 166 , 1597, September 8, 2016 1597