Cell - 8 September 2016

Supplemental Figures

1 x

Mix

ed

Beer 2

WA

(^) As
ia
Origin
Beer
Wine
Spirits
Saké
Wild
Bio-ethanol
Bread
Laboratory
S.paradoxus
(^) Belg
ium/
Germa
ny
Win
e
US
0.005
Beer 1
Lineage
Mixed
Wine
Beer 2
West Africa
Asia
Britain
US
Belgium/Germany
Brit
ain
Beer^
1
BE062
BE008
WL003
BE016
BI003
WI005
BE079
SP010
BE069
BE057
BE007
BE037
BE074
BE065
BE031
BE021
BE052
WI015
BI004
BE097
(^950) EB
BE055
WL001
WL004
BE068BE035
BE070
SA007
BR001BR003
SP007
BE001
WI013
BE003
BE082
BE034
BE002
BE100
BE005
BE024BE088
BE049
BE056
BE092
BE076
BE085
BR002
WI018
BE075BE042
BE091
BE102
WI001
SP003
BE061
spar
WI003
SP006
SP005 BE067
BI001
SP002
BE101
BE006
BE063
BE026
SA005
(^590) EB
WL006
BE041
WI006
BE060
230 EB
BE043
BE098
BE009
BE020
BE096
BE080
BE027BE004
LA002
BE029BE028
SA001
BE058
WI009
WI004
BE066
BE011
BE081
BR004
BE019
BE038
SP011
BE014
BE047
SP001
BE073
WI019
BE039
BE071
BE015
BE025
BE093
BE033
BE083
SA002
BE013
BE050
BE072
BE018
BE086
WI012
BE078
BE045
WI007
BE077
WI010
BE023 BE054
150 EB
WI014
BE090
BI002
BE044
WL005
BE064
SP008
BE040
WI016
BE046
SA003
WI002
BE017
WL002
BE022
WI008
BE087
SP009
SP004
LA001
SA006
BE048
WI017
BI005
SA004
BE053
BE030
WL007 BE036
BE084
BE099
BE010
BE012
WI011
BE089
BE094

• Origin
  Wild
  Clinical
  Fermented source
  Laboratory
  NA
  S.paradoxus
  AB
  0.002
  C
  0.00
  0.50
  1.00
  0.00
  0.50
  1.00
  0.00
  0.50
  1.00
  0.00
  0.50
  Estimated ancestry (Q)1.00
  Britain USGermanyBelgium/ Mixed Wine Beer 2 Asia Mosaic NS
  K=2
  K=4
  K=6
  K=8
  BE047BE048BE049BE053BE054BE055BE056BE064BE069BE070BE079BE089BE100BE101BE001BE009BE010BE037BE090BE066BE050BE036BE045BE099BE094WI012BE065BE067BE071BE082BE098BE102BE007BE068BE044BE051BE046BE073BE075BE076BE077BE078BE081BE087BE008BE012BE016BE022BE026BE041SP005BE031BE015BE043BE061WL005WL006WL007BE025SP003BR002BR003BR004BR001BE028BE023BE006BE029SP001BE038BE005SP011BE088BE014BE020BE024BE030BE033WI001WI003WI004WI005WI006WI007WI009WI010WI011WI013WI014WI015WI017WI018SA002SP002BE086BE092BE002BE032BE003BE063BE021WI019BE083BE084BE085BE091BE004BE011BE027BE034BE039BE040BE080BE013BE062BE059SA001SA003SA004SA005SA006SA007BI001BI003BI004WL004WI002WL002WL003WL001LA001SP004SP006WI016BI005BI002LA002BE018SP010BE017BE074BE072BE093BE035BE060BE019BE057WI008SP008SP007SP009BE058BE042BE052BE095BE096BE097
  ZP590
  BJ3
  SP004
  BE041
  WI018
  SA005
  YJM1418
  ZP578
  BE083
  YJM326
  Kyokai7
  YJM1342
  BE024
  BJ17
  WI002
  EXF7145
  ZP680
  BE027
  YJM1401
  YJM1341
  YJM1248
  BJ9
  BE038
  BJ23
  YJM981
  XJ6
  YN2BI003
  ZP656
  265 P
  Z
  YJM1615
  LA002
  YJM1388
  BE065
  YJM1439
  YJM1244
  YJM244
  HN1
  BE006
  UC5
  Vin13
  BE035
  YN4
  BE004
  YJM682
  XJ7
  W303
  HLJ3
  ZP579
  BI001
  BE022
  (^14) 5P
  Z
  EXF6780
  ZP786
  BE081
  BE001
  FJ11 HLJ2
  Y10
  BE008
  UWOPS03-461.4
  BE102
  SP010
  AN3e1s1
  WL005
  247 PZ
  BJ19
  BE098
  BJ18
  HN2
  EC1118
  YJM450
  BE046
  YJM1400
  ZP611
  BE052
  YJM1129
  BJ5
  ZP1041
  HN8
  BE093
  WI003
  ZP823
  YN5
  spar
  Y12
  ZP793
  FJ10
  HLJ1
  BE075
  WI019
  SD3
  SX2
  WL007
  WI004
  BE048
  WL003
  BE029
  XJ3
  YJM1444
  YJM1336
  YJM1419
  BE080
  YJM554
  ZP796
  BR004
  BE025
  YJM453
  BE077
  BE039
  YJM1356
  SA006
  BE050
  BE068
  YJM193
  YJM627
  BE051
  BE096
  SX7
  YJM1460
  BE085
  DBVPG1106
  WI012
  YJM1385
  YJM270
  BE047
  YS9
  CLIB324
  DBVPG10100
  YJM1199
  ZP736
  HN14
  ZP653
  SX8
  PYR4b
  ZP785
  BJ28
  SX9 YJM451
  HN7
  BI004
  SX1
  SDO8s1SM69s1
  YJM1526
  BE099
  YJM1477
  YJM1549
  SDO2s1
  BJ21
  YJM1415
  BE015
  FJ9
  OakArd11
  SDO6s1YJM1434
  WL002
  SA002
  DBVPG1373
  FJ5
  FostersB
  ZP577YJM993
  YJM1307
  CLIB215
  BE010
  BE017
  BE095
  YJM978
  BE030
  ZP781
  FJ4
  IOC9002
  XJ2
  FJ2
  YJM1450
  YJM1573
  YJM1386
  BE086
  BE071
  ZP817
  BE100
  YJM990
  BE097 BJ16
  CBS7960ZP862
  AN1g2s1
  YJM1399 ZP565
  WI010
  BR003
  WL006
  BE040
  YJM1202
  ZP575
  YJM969
  YJM1478
  YJM689
  BE054
  YJM1527
  YJM1574
  XJ4
  YJM1190
  FJ8
  BE031
  SP007
  (^654) MJ
  Y
  Dav1e
  BE057
  HN17
  BJ15
  s288c
  YN6
  BE056
  BJ12
  YJM470
  ZP1050
  SD1
  BE067
  YJM1273
  BE011 WI001
  BE069
  BE087
  HN6
  ZP570
  CEN.PK2
  BE088
  BJ13
  BJ26
  BI005
  UWOPS87-2421
  NX1
  YJM1592
  BE070
  ZP530
  L1528
  BJ4
  FJ7
  ZP779
  YJM681
  BJ8
  WL004
  SX6
  BR002
  BE060
  SK1
  YJM1479
  BE037
  ZJ2
  BE043
  JL5
  EXF6719
  SP001
  DBVPG6044
  WI017
  AWRI796
  SX5
  HN16
  ZP561
  YJM975
  YJM1381
  SD4
  ZP850
  BE089
  NX3
  DBVPG6765
  YJM1332
  SDO3s1
  YJM1417
  BE072
  ZP851
  YJM1133
  SA004
  YJM984
  BE049
  WL001
  BE026
  WI005
  YN1
  BE045
  WI013
  BE064
  ZP633
  JL1
  SP003
  1 M 344
  JY
  BE013
  YJM972
  EXF6761
  HN4
  7 T
  HN3
  WI016
  BJ25
  SP006
  LalvinQA23
  BJ7
  YJM271
  BJ27
  NX2
  BE044
  SX4
  BE033
  HN13
  HUN9.1s1
  ZTW1
  BE012
  BJ6
  ZP641
  BE082
  WI008
  YPS128
  BE058
  WI007
  JL2
  YPS163
  YJM1242
  BJ1
  PW5
  YJM987
  BE079
  BE018
  BE034
  WI006
  BE005
  EXF7179 YJM1326
  JL3
  YJM555
  XJ1
  HN15
  BE059
  SX3
  SON4c SD2
  ZP560 YJM1250
  BE020
  YJM1311
  YJM1083
  EXF7200
  YJM320
  BE073
  YJM195
  HN19
  UWOPS83-787.3
  SX10
  YJM189
  BE101
  ZP651
  SP008
  YJM1208
  BR001
  YJM1389
  BI002
  ZP860
  YJM683
  BE063
  WI009
  BE021
  ZP675
  SP009
  BE028
  BE036
  BJ10
  SA001
  YJM1387
  XJ5
  ZP652
  BE053
  HN11
  BJ22
  SP002
  ZJ1
  YN3
  HN9
  WI015
  BE042
  BE074
  SP011
  BE014
  BE091
  OakBor21-1
  HN12
  OakRom3
  BE009
  FJ3
  BE032
  FJ1
  ZP848
  SA007
  BE094
  ZP636
  HN5
  BE019
  FJ6
  RedStar
  BE061
  VL3
  YJM1433
  BJ14
  BE078
  YJM428
  SX11
  BE084
  BE066
  HN18
  BE002
  YJM1447
  BE062
  BE055
  BE092
  YJM1338
  ZP566
  FJ12
  BE023
  BE007
  WI011
  BJ20
  YJM1383
  BE090
  BJ2
  HN10
  YJM1355
  YJM996
  SA003
  SP005
  BE003
  YJM541
  YJM339
  BE076
  FostersO
  Y55
  WI014
  (^365) P
  Z
  EC9-8
  BJ24
  JL4
  YJM1402
  BE016
  Sigma1278bYJM693
  ZP861
  ZP568
  YJM1304
  AWRI1631
  YJM1463
  LA001
  OakGri7
  Figure S1. Phylogeny and Population Structure of the IndustrialS. cerevisiaeStrains, Related toFigures 1A–1C
  (A) Phylogenetic tree of strains sequenced in this study, usingSaccharomyces paradoxusas an outgroup. The tree was inferred from the concatenation matrix of
  2,020 single copy orthologs. Black dots on nodes indicate bootstrap support values < 70%. Color codes indicate origin (names) and lineage (circular bands). The
  basal splits of the five industrial lineages are indicated with a colored dot. Branch lengths reflect the average number of substitutions per site (scale bar = 0.005
  substitutions per site).
  (B) Population structure plot, with strain codes indicated.
  (legend continued on next page)