Cell - 8 September 2016

(C) Maximum likelihood phylogenetic tree inferred from a concatenated alignment of nine partial genes of 450S. cerevisiaeisolates, usingS. paradoxusas an
outgroup. Strains are colored according to origin. For a list of the included strains and corresponding references, seeTable S2. Branch lengths reflect the average
number of substitutions per site (scale bar = 0.002 substitutions per site). Dots indicate nodes with bootstrap support values > 50%. Font color codes indicate
origin: wild (blue), clinical (orange), fermented source (green), laboratory (gray), not available (NA) (dark gray),S. paradoxus(black).