Response to Comment on “Impact of
neurodegenerative diseases on human adult
hippocampal neurogenesis”
J. Terreros-Roncal, E. P. Moreno-Jiménez,
M. Flor-García, C. B. Rodríguez-Moreno,
M. F. Trinchero, B. Márquez-Valadez, F. Cafini,
A. Rábano, M. Llorens-Martín
Rakic and colleagues challenge the use of
extensively validated adult hippocampal
neurogenesis (AHN) markers and postulate an
alternative interpretation of some of the data
included in our study. In Terreros-Roncal et al.,
reconstruction of the main stages encom-
passed by human AHN revealed enhanced
vulnerability of this phenomenon to neuro-
degenerative diseases. Here, we clarify points
and ambiguities raised by these authors.
Full text: dx.doi.org/10.1126/science.abn7270Comment on “Impact of neurodegenerative diseases
on human adult hippocampal neurogenesis”
Arturo Alvarez-Buylla, Arantxa Cebrian-Silla,
Shawn F. Sorrells, Marcos Assis Nascimento,
Mercedes F. Paredes, Jose Manuel Garcia-Verdugo,
Zhengang Yang, Eric J. Huang
Terreros-Roncal et al. (Research Article,
26 November 2021, p. 1106) investigated the
impacts of human neurodegeneration on
immunostainings assumed to be associatedwith neurogenesis. However, the study pro-
vides no evidence that putative proliferating
cells are linked to neurogenesis, that multipo-
lar nestin+ astrocytes are progenitors, or that
mature-looking doublecortin+ neurons are
adult-born. Their histology-marker expres-
sion differs from what is observed in species
where adult hippocampal neurogenesis is
well documented.
Full text: dx.doi.org/10.1126/science.abn8861Response to Comment on “Impact of neuro-
degenerative diseases on human adult hippocampal
neurogenesis”
J. Terreros-Roncal, E. P. Moreno-Jiménez,
M. Flor-García, C. B. Rodríguez-Moreno,
M. F. Trinchero, B. Márquez-Valadez, F. Cafini,
A. Rábano, M. Llorens-Martín
Alvarez-Buylla et al. provide an alternative
interpretation of some of the data included
in our manuscript and question whether
well-validated markers of adult hippocampal
neurogenesis (AHN) are related to this phe-
nomenon in our study. In Terreros-Roncal
et al., reconstruction of the main stages of
human AHN revealed its enhanced vulnera-
bility to neurodegeneration. Here, we clarify
ambiguities raised by these authors.
Full text: dx.doi.org/10.1126/science.abo0920- “4,000+ Russian scientists, science journalists pen
open letter against Ukraine war,” Science the Wire
(2022); https://science.thewire.in/the-sciences/4750-
russian-scientists-science-journalists-sign-open-letter-
against-ukraine-war/.
COMPETING INTERESTS
J.H. is a pro-bono senior adviser to the president of the
Woodwell Climate Research Center. The center has coopera-
tive relationships with Russian scientists working on monitor-
ing environmental change in the Arctic.
Published online 24 March 2022
10.1126/science.abq1025
TECHNICAL COMMENT ABSTRACTS
Comment on “Impact of neurodegenerative diseases
on human adult hippocampal neurogenesis”
Jon I. Arellano, Alvaro Duque, Pasko Rakic
Terreros-Roncal et al. ( Research Article,
26 November 2021, p. 1106) report the
presence of abundant neurogenesis in the
adult human hippocampus based mainly
on immunolabeling with doublecortin,
while identifying very low numbers of
progenitors, which are not shown to be pro-
liferative. We discuss this and other flaws
in the interpretation of their data that raise
questions about their conclusions.
Full text: dx.doi.org/10.1126/science.abn7083
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