The Human Brain During the Third Trimester

St

ria

me

du

llar

is

White matterWhite matter

Cortical platCortical platee

LaLayer yer II

HYPO-

THALAMUS

HYPO-

THALAMUS

AMYGD

AL

A

AMYGD

AL

A

BASAL

GANGLIA

BA SAL

GANGLIA

TTe mporal lobeemporal lobe

Lateral

fissure

Central sulcus

PutamenPutamen

Inferior temporal

gyrus

Inferior temporal

gyrus

Post-

central

gyrus

Po st-

central

gyrus

Callosal

glioepithelium

Lateral migratory stream

(infiltrates claustrum and

penetrates insular cortex)

Lateral migratory stream

(infiltrates claustrum and

penetrates insular cortex)

Lateral migratory stream

(extends to paracentral cortex)

Lateral migratory stream

(extends to paracentral cortex)

Lateral migratory stream

(extends to temporal neocortex)

Lateral migratory stream

(extends to temporal neocortex)

V

en

tr

a

l

st

ri

a

tu

m

V

en

tr

a

l

st

ri

a

tu

m

Interhemispheric

fissure

Induseum

griseum

Lateral

mammillary

nucleus

Lateral

mammillary

nucleus

Antero-

ventral

nucleus

Antero-

ventra l

nucleus

Medial

mammillary

nucleus

Medial

mammillary

nucleus

Glob

us pallidus

(inter

nal segment)

Glob

us pallidus

(inter

nal segment)

Glob

us pallidus

(exter

nal segment

)

Glob

us pallidus

(exter

nal segment

)

Cave of the

septum

Cave of th e

septum

I

n

s

u

l

a

r

g

y

r

u

s

I

n

s

u

l

a

r

g

y

r

u

s

Superior temporal

gyrus

Superior temporal

gyrus

Middle temporal

gyrus

Middle temporal

gyrus

InterIntercalated massescalated masses

Central

nucleus?

Central

nucleus?

Abnormal

hemorrhage in the

germinal matrix

Abnormal

hemorrhage in the

germinal matrix

FFornixornix

A

n

te

rio

r

co

m

m

is

su

re

A

n

te

rio

r

co

m

m

is

su

re

CCoorrppuussccaalllloossuumm((bbooddyy))

Optic

trac

t

Optic

trac

t

E

x

t

e

r

n

a

l

c

a

p

us

el

E

x

t

e

r

n

a

l

c

a

p

us

el

Subfornical

organ?

Subfornical

organ?

Lateral ve ntricle

Ventral

anterior

nucleus

Ventral

anterior

nucleus

Ventral

anterior

nucleus

Ve ntral

anterior

nucleus

M

ed

u

ll

a

ry

la

m

in

a

M

ed

u

ll

a

ry

la

m

in

a

Choroid

plexus

Choroid

plexus

V

E

N

T

R

A

L

C

O

M

P

L

E

X

V

E

N

T

R

A

L

C

O

M

P

L

E

X

A

N

T

ER

IO

R

C

O

M

PLEX

A

N

T

E

R

IO

R

C

O

M

PLEX

THALAMUSTHALAMUS

R

e

ti

c

u

la

r

n

u

c

le

u

s

R

e

ti

c

u

la

r

n

u

c

le

u

s

R

E

T

IC

U

L

A

R

B

E

L

T

R

E

T

IC

U

L

A

R

B

E

L

T

CeCeCeCerrre bral pedunclerebral peduncleebral peduncleebral peduncle

Forel's

fields

Fo rel's

fields

Reuniens

nucleus?

Reuniens

nucleus?

Massa

intermedia

Massa

intermedia

Hippocampus

(Ammon's horn)

Hippocampus

(Ammon's horn)

Lateral Lateral ventricleventricle

Cingulum

Cingulate

gyrus

Cingulate

gyrus

Ansa lenticularis?Ansa lenticularis?

Stria terminalis?Stria terminalis?

Caudate (tail)Caudate (tail)

Entorhinal cortex

SubiculuSubiculumm

PParacentral lobulearacentral lobule

C

al

u

s

rt

u

m

C

al

u

s

rt

u

m

Fornix and

mammillo-

thalamic

tract

Fornix and

mammillo-

thalamic

tract

Supra-

mammillary

area

Supra-

mammillary

area

P

a

ra

ce

nt

ra

l

nu

cl

eu

s

P

a

ra

ce

nt

ra

l

nu

cl

eu

s

Dorsomedial

nucleus

Dorsomedial

nucleus

St

ria

me

du

llar

is

Anteromedial

nucleus

Anteromedial

nucleus

Ventral

lateral

nucleus

Ve ntral

lateral

nucleus

Subthalamic

nucleus

Subthalamic

nucleus

Ventral

medial

nucleus

Ve ntral

medial

nucleus

Centro-

median

nucleus

Centro -

median

nucleus

C

E

N

T

R

A

L

C

O

M

P

L

E

X

C

E

N

T

R

A

L

C

O

M

P

L

E

X

DORSAL

COMPLEX

DORSAL

COMPLEX

PERIVEN-

TRICULAR

COMPLEX

PERIVEN-

TRICULAR

COMPLEX

SUBTHALAMUSSUBTHALAMUS

Zona

incerta

Zona

incerta

Pa racentral neuroepithelium and subventricular zone

Pa racentral stratified transitional field

Subpial

granular

layer

Temporal stratified

transitional field

Te mporal stratified

transitional field

Temporal neuro-

epithelium and

subventricular zone

Te mporal neuro-

epithelium and

subventricular zone

Choroid plexus

stem cells?

Choroid plexus

stem cells?

Fornical

glioepithelium

Fo rnical

glioepithelium

Stria

terminalis

Stria

terminalis

Third

ventricl e

Third

ventricl e

Fo

ra

m

en

of

M

on

ro

Germinal and transitional structures in italics

Caudat

e

(tail)

Caudat

e

(tail)

Anteromedial/posterior

striatal neuroepithelium

and subventricular zone

Anteromedial/posterior

striatal neuroepithelium

and subventricular zone

Strionuclear glioepitheliuStrionuclear glioepitheliumm

Posterior striatal

neuroepithelium

and subventricular

zone

Po sterior striatal

neuroepithelium

and subventricular

zone

Hypothalamic

glioepithelium/

ependyma

Hypothalamic

glioepithelium/

ependyma

Thalamic

glioepithelium/

ependyma

Thalamic

glioepithelium/

ependyma

Inter

nal capsule (central/posterior limb)

Inter

nal capsule (central/posterior limb)

Alvear

glioepithelium

Alvear

glioepithelium

Amygdaloid

glioepithelium/ependyma

Amygdaloid

glioepithelium/ependyma

PLATE 180B