HUMAN BIOLOGY

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86 Chapter 4


Despite being controversial,
embryonic stem cells have a
key advantage over adult ones.
The adult stem cells can give
rise to a few types of tissues—
such as cartilage—but embryonic
stem cells can, in theory, give
rise to all the different types of
body tissues. Recently, however, research teams in Japan and
the United States succeeded in chemically coaxing adult stem
cells from mice to behave much more like embryonic ones.
The process—briefly “shocking” the adult cells with an acidic
bath—is relatively simple. If it can work with adult stem cells
from humans, it may be the basis for therapies that use adult
stem cells to regenerate cells a damaged tissue needs to heal
from injury or disease.

your Future



  1. After you eat too many carbohydrates and proteins, your
    body converts the excess to storage fats, which accumulate
    in.
    a. loose connective tissue c. adipose tissue
    b. dense connective tissue d. both b and c

  2. The body’s internal environment consists of.
    a. blood plasma c. the five body cavities
    b. interstitial fluid d. both a and b

  3. In , physical and chemical aspects of the body
    are being kept within tolerable ranges by controlling
    mechanisms.
    a. positive feedback c. homeostasis
    b. negative feedback d. metastasis

  4. detect specific environ mental changes, an
    pulls different bits of information together in the selection
    of a response, and carry out the response.

  5. Match the concepts:
    muscles and glands a. integrating center
    positive feedback b. reverses an altered
    sites of body receptors condition
    negative feedback c. eyes and ears
    brain d. effectors
    e. intensifies the original
    condition


CritiCaL thinKing



  1. In people who have the genetic disorder anhidrotic
    ectodermal dysplasia, patches of tissue have no sweat
    glands. What kind of tissue does this disorder affect?

  2. The disease called scurvy results from a deficiency of
    vitamin C, which the body uses to synthesize collagen.
    Explain why scurvy sufferers tend to lose teeth, and why
    any wounds heal much more slowly than normal, if
    at all.

  3. The man pictured in
    Figure 4.17 wears skin
    ornaments applied by
    piercing. Among other
    functions, the skin is a
    barrier to potentially
    dangerous bacteria, and
    some people object to
    extensive body piercing
    on the grounds that
    it opens the door to
    infections. Explain why
    you do or don’t agree
    with this objection.

  4. Porphyria is a genetic
    disorder. In one form,
    affected people lack
    enzymes of a metabolic
    pathway that forms heme,
    the iron-containing group
    in hemoglobin. Chemicals called porphyrins accumulate and
    cause terrible symptoms, especially if the person is exposed


SPL/Science Source

to sunlight. Sores and
scars form on the skin
(Figure 4.18). The gums
shrink away from the
teeth and the canine teeth
may begin to look like
fangs. Drinking alcohol
or eating garlic makes
symptoms worse. People
with porphyria can avoid
sunlight and aggravating
substances. They also can
get injections of heme
from normal red blood
cells. If you are familiar
with vampire stories,
which date from centuries
ago, can you think of a
reason why they may
have arisen among people
who knew nothing about
the cause of porphyria?


  1. Your housemate comes down with the latest stomach
    flu virus and develops frequent, watery diarrhea that
    alternates with vomiting episodes. After a day of misery,
    she is so listless that you insist on taking her to the
    emergency room. A nurse hooks her up to an IV drip
    of saline solution (slightly salty water) and insists that
    she stay in ER until the full amount has entered her
    bloodstream. Why was this the appropriate emergency
    treatment for your housemate?


F i g u r e 4.18 Sun exposure
causes ulcers and blisters to
form on the skin of a person
affected by porphyria.

F i g u r e 4.17 This young man
has chosen to undergo
multiple body piercings.

Jason Todd/Photonica/Getty Images

DR Zara/AGE Fotostock

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