289Kinoshita N, Iioka H, Miyakoshi A, Ueno N (2003) PKC delta is essential for Dishevelled func-
tion in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.
Genes Dev 17:1663–1676
Kirschner M, Gerhart JC, Hara K, Ubbels GA (1980) Initiation of the cell cycle and establishment
of bilateral symmetry in Xenopus eggs. Symp Soc Dev Biol 38:187–215
Kishimoto Y, Lee KH, Zon L, Hammerschmidt M, Schulte-Merker S (1997) The molecular
nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.
Development 124:4457–4466
Klein SL, Moody SA (2015) Early neural ectodermal genes are activated by siamois and twin dur-
ing blastula stages. Genesis 53:308–320. doi:10.1002/dvg.22854
Kloc M (2009) Teachings from the egg: new and unexpected functions of RNAs. Mol Reprod Dev
76:922–932. doi:10.1002/mrd.21043
Knoetgen H, Viebahn C, Kessel M (1999) Head induction in the chick by primitive endoderm of
mammalian, but not avian origin. Development 126:815–825
Kochav S, Eyal-Giladi H (1971) Bilateral symmetry in chick embryo determination by gravity.
Science 171:1027–1029
Kofron M, Birsoy B, Houston D et al (2007) Wnt11/beta-catenin signaling in both oocytes and
early embryos acts through LRP6-mediated regulation of axin. Development 134:503–513.
doi:10.1242/dev.02739
Kohn AD, Moon RT (2005) Wnt and calcium signaling: β-catenin-independent pathways. Cell
Calcium 38:439–446. doi:10.1016/j.ceca.2005.06.022
Koos DS, Ho RK (1999) The nieuwkoid/dharma homeobox gene is essential for bmp2b repression
in the zebrafish pregastrula. Dev Biol 215(2):190–207
Kozmik Z, Holland LZ, Schubert M et al (2001) Characterization of amphioxusamphivent, an
evolutionarily conserved marker for chordate ventral mesoderm. Genesis 29:172–179.
doi:10.1002/gene.1021
Kraft B, Berger CD, Wallkamm V et al (2012) Wnt-11 and Fz7 reduce cell adhesion in convergent
extension by sequestration of PAPC and C-cadherin. J Cell Biol 198:695–709. doi:10.1083/
jcb.201110076
Kramps T, Peter O, Brunner E et al (2002) Wnt/wingless signaling requires BCL9/legless- mediated
recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109:47–60
Krasnow R, Adler P (1994) A single frizzled protein has a dual function in tissue polarity.
Development 120:1883–1893
Kreuger J, Perez L, Giraldez AJ, Cohen SM (2004) Opposing activities of Dally-like glypican
at high and low levels of Wingless morphogen activity. Dev Cell 7:503–512. doi:10.1016/j.
devcel.2004.08.005
Ku M, Melton DA (1993) Xwnt-11: a maternally expressed Xenopus wnt gene. Development
119:1161–1173
Kuhl M, Sheldahl LC, Malbon CC, Moon RT (2000) Ca(2+)/calmodulin-dependent protein kinase
II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus.
J Biol Chem 275:12701–12711
Kuroda H, Wessely O, De Robertis EM (2004) Neural induction in Xenopus: requirement for ecto-
dermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus. PLoS
Biol 2:E92. doi:10.1371/journal.pbio.0020092
Kurth T, Hausen P (2000) Bottle cell formation in relation to mesodermal patterning in the Xenopus
embryo. Mech Dev 97:117–131. doi:10.1016/S0925-4773(00)00428-7
Kwon H-J, Bhat N, Sweet EM et al (2010) Identification of early requirements for preplacodal
ectoderm and sensory organ development. PLoS Genet 6:e1001133. doi:10.1371/journal.
pgen.1001133
Ladher R, Mohun TJ, Smith JC, Snape AM (1996) Xom: a Xenopus homeobox gene that mediates
the early effects of BMP-4. Development 122:2385–2394
Lamb TM, Knecht AK, Smith WC et al (1993) Neural induction by the secreted polypeptide nog-
gin. Science 262:713–718
6 Vertebrate Axial Patterning: From Egg to Asymmetry