371Izpisua-Belmonte JC, De Robertis EM, Storey KG, Stern CD (1993) The homeobox gene goosec-
oid and the origin of organizer cells in the early chick blastoderm. Cell 74:645–659
Jacobson M, Hirose G (1978) Origin of the retina from both sides of the embryonic brain: a con-
tribution to the problem of crossing at the optic chiasma. Science 202:637–639
Jacobson M, Hirose G (1981) Clonal organization of the central nervous system of the frog:
II. Clones stemming from individual blastomeres of the 32- and 64-cell stages. J Neurosci
1:271–284
Jones CM, Armes N, Smith JC (1996) Signalling by TGF-beta family members: short-range
effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin. Curr Biol
6:1468–1475
Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV (1995) Nodal-related signals induce axial
mesoderm and dorsalize mesoderm during gastrulation. Development 121:3651–3662
Joseph EM, Melton DA (1997) Xnr4: a Xenopus nodal-related gene expressed in the Spemann
organizer. Dev Biol 184:367–372
Joseph EM, Melton DA (1998) Mutant Vg1 ligands disrupt endoderm and mesoderm formation in
Xenopus embryos. Development 125:2677–2685
Joubin K, Stern CD (1999) Molecular interactions continuously define the organizer during the
cell movements of gastrulation. Cell 98:559–571
Jovelin R, He X, Amores A, Yan Y-L, Shi R, Qin BY, Roe B, Cresko W, Postlethwait J (2007)
Duplication and divergence of fgf8 functions in teleost development and evolution. J Exp Zool
(Mol Dev Biol) 308B:730–743
Kalinka AT, Varga KM, Gerrard DT, Preibisch S, Corcoran DL, Jarrells J, Ohler U, Bergman CM,
Tomancak P (2010) Gene expression divergence recapitulates the developmental hourglass
model. Nature 468:811–814
Kane D, Adams R (2002) Life at the edge: epiboly and involution in the zebrafish. Results Probl
Cell Differ 40:117–135
Kane DA, Kimmel CB (1993) The zebrafish midblastula transition. Development 119:447–456
Karabagli H, Karabagli P, Ladher RK, Schoenwolf GC (2002) Comparison of the expression pat-
terns of several fibroblast growth factors during chick gastrulation and neurulation. Anat
Embryol (Berl) 205:365–370
Karasaki S (1963) Studies on amphibian yolk: 5. Electron microscopic observations on the utiliza-
tion of yolk platelets during embryogenesis. J Ultrastruct Res 59:225–247
Keezer WS (1965) Spontaneous generation, pre-formation and epigenesis. Bios 36:26–32
Keller PJ, Schmidt AD, Wittbrodt J, Stelzer EH (2008) Reconstruction of zebrafish early embry-
onic development by scanned light sheet microscopy. Science 322:1065–1069
Keller RE (1975) Vital dye mapping of the gastrula and neurula of Xenopus laevis: I. Prospective
areas and morphogenetic movements of the superficial layer. Dev Biol 42:222–241
Keyte AL, Imam T, Smith KK (2007) Limb heterochrony in the marsupial Monodelphis domes-
tica. J Morphol 268:1092
Keyte AL, Smith KK (2010) Developmental origins of precocial forelimbs in marsupial neonates.
Development 137:4283–4294
Khaner O (1998) The ability to initiate an axis in the avian blastula is concentrated mainly at a
posterior site. Dev Biol 194:257–266
Khaner O, Eyal-Giladi H (1989) The chick’s marginal zone and primitive streak formation:
I. Coordinative effect of induction and inhibition. Dev Biol 134:206–214
Kholodenko BN, Bruggeman FJ, Sauro HM (2005) Mechanistic and modular approaches to mod-
eling and inference of cellular regulatory networks. In: Systems biology. Springer.
pp 143–159
Kiecker C, Bates T, Bell E (2016) Molecular specification of germ layers in vertebrate embryos.
Cell Mol Life Sci 73:923–947
Kimelman D (2006) Mesoderm induction: from caps to chips. Nat Rev Genet 7:360–372
Kimelman D, Kirschner M (1987) Synergistic induction of mesoderm by FGF and TGF-beta and
the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell
51:869–877
7 Establishment of the Vertebrate Germ Layers