43Petersen C, Berridge MJ, Borgese MF, Bennett DL (1995) Putative capacitative calcium entry
channels: expression of Drosophila trp and evidence for the existence of vertebrate homo-
logues. Biochem J 311:41–44
Polzonetti V, Cardinali M, Mosconi G, Natalini P, Meiri I, Carnevali O (2002) Cyclic ADPR and
calcium signaling in sea bream (Sparus aurata) egg fertilization. Mol Reprod Dev 61:213–217.
doi:10.1002/mrd.1150
Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, Jacobsen SE, Reik W (2010)
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID
deficiency. Nature 463:1101–1105. doi:10.1038/nature08829
Prasad SV, Skinner SM, Carino C, Wang N, Cartwright J, Dunbar BS (2000) Structure and func-
tion of the proteins of the mammalian Zona pellucida. Cells Tissues Organs 166:148–164.
doi:10.1159/000016730
Rice A, Parrington J, Jones KT, Swann K (2000) Mammalian sperm contain a Ca2+-sensitive phos-
pholipase C activity that can generate InsP 3 from PIP 2 associated with intracellular organelles.
Dev Biol 228:125–135. doi:10.1006/dbio.2000.9929
Ridgway EB, Gilkey JC, Jaffe LF (1977) Free calcium increases explosively in activating medaka
eggs. Proc Natl Acad Sci U S A 74:623–627
Robinson R (2008) For Mammals, Loss of yolk and gain of milk went hand in hand. PLoS Biol
6:e77. doi:10.1371/journal.pbio.0060077
Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K (2004) Phospholipase Cζ causes
Ca2+ oscillations and parthenogenetic activation of human oocytes. Reproduction 128:697–
- doi:10.1530/rep.1.00484
Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA,
Wagner SL, Cahalan MD (2005) STIM1, an essential and conserved component of store-
operated Ca2+ channel function. J Cell Biol 169:435–445. doi:10.1083/jcb.200502019
Runft LL, Watras J, Jaffe LA (1999) Calcium release at fertilization of Xenopus eggs requires type
I IP 3 receptors, but not SH2 domain-mediated activation of PLCγ or Gq-mediated activation of
PLC β. Dev Biol 214:399–411. doi:10.1006/dbio.1999.9415
Sagata N, Oskarsson M, Copeland T, Brumbaugh J, Vande Woude GF (1988) Function of c-mos
proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature 335:519–525.
doi:10.1038/335519a0
Sakai N, Burgess S, Hopkins N (1997) Delayed in vitro fertilization of zebrafish eggs in Hank's
saline containing bovine serum albumin. Mol Mar Biol Biotechnol 6:84–87
Sato K (2008) Signal transduction of fertilization in frog eggs and anti-apoptotic mechanism in
human cancer cells: common and specific functions of membrane microdomains. Open
Biochem J 2:49–59. doi:10.2174/1874091X00802010049
Satouh Y, Nozawa K, Ikawa M (2015) Sperm postacrosomal WW domain-binding protein is not
required for mouse egg activation. Biol Reprod 93:94. doi:10.1095/biolreprod.115.131441
Saunders CM, Larman MG, Parrington J, Cox LJ, Royse J, Blayney LM, Swann K, Lai FA (2002)
PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development.
Development 129:3533–3544
Saunders CM, Swann K, Lai FA (2007) PLCzeta, a sperm-specific PLC and its potential role in
fertilization. Biochem Soc Symp 74:23–36. doi:10.1042/BSS0740023
Schatten G (1994) The centrosome and its mode of inheritance: the reduction of the centrosome
during gametogenesis and its restoration during fertilization. Dev Biol 165:299–335.
doi:10.1006/dbio.1994.1256
Schatten G, Simerly C, Schatten H (1985) Microtubule configurations during fertilization, mitosis,
and early development in the mouse and the requirement for egg microtubule-mediated motil-
ity during mammalian fertilization. Proc Natl Acad Sci U S A 82:4152–4156
Schatten H, Sun QY (2009) The role of centrosomes in mammalian fertilization and its signifi-
cance for ICSI. Mol Hum Reprod 15:531–538. doi:10.1093/molehr/gap049
Schindler K, Schultz RM (2009) CDC14B acts through FZR1 (CDH1) to prevent meiotic matura-
tion of mouse oocytes. Biol Reprod 80:795–803. doi:10.1095/biolreprod.108.074906
Schoenwolf GC (1997) Reptiles and embryos. In: Gilbert SF, Raunio AM (eds) Embryology.
Constructing the organism. Sinauer Associates, Inc. Publishers, Sunderland
1 Egg Activation at Fertilization