Vertebrate Development Maternal to Zygotic Control (Advances in Experimental Medicine and Biology)

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540


Cell division (cont.)
mitotic spindle, 148
scaling, 149
Xenopus, 147
Cell division cycle protein 2 (Cdc2), 86
Cell-fate determinants, 61–63, 65
localized mRNAs
VegT mRNA, 61
Vg1 mRNA, 61
Wnt11b mRNA, 62
translational regulation
BMP signaling pathway, 63, 65
FGFR signaling pathway, 62
Centrosome attracting body (CAB), 145,
146, 412
Chromatin, 494, 504, 517–520
Chromosomal passenger complex (CPC), 98,
121–123, 131, 153
Clearance, parental products, 489, 493,
514–520
accumulation, maternal factors, 493
elimination of parental factors, 493
epigenetic marks (see Parental epigenetic
marks)
maternal (see Maternal RNA clearance)
mitochondria elimination, 521–522
OET (see Oocyte-to-embryo transition
(OET))
phases, 494
yolk consumption, 520–521
Cleavage pattern determination, 133–137
Xenopus
anuran amphibian eggs, 136
blastomeres cleavage planes, 135
canonical cleavage pattern, 135
holoblastic, 136
mechanistic model, 137
spindle alignment, 136
zebrafish
blastomeres, 133, 134
furrow orientation pattern, 134
meroblastic cleavage, 133
metaphase asters, 134
sperm-aster centering, 133
stereotypic cleavage pattern, 135
c-Mos, 9, 60, 102, 104
Cortical rotation, 211, 212
amphibian, 215–219
anamniotes (icthyopsids) and reptiles, 273
embryonic asymmetries, 52–53
zebrafish, 219–221
CPE-binding proteins (CPEBs), 501, 512
CpG methylation, 515


Cripto-1 mRNA translation
luciferase reporter assay, 66, 68
nodal signaling pathway, 66
Cullin-like subunit Apc2, 89
Cyclin-dependent kinase (Cdk)
CAK, 87
Cdc2, 86
Cdk1 autoamplification loop, 87–89
Cdk2 shares, 86
in mammalian cells, 86
regulatory cyclin subunit, 86
T-loop (activation loop) blocks access, 87
Cyclin-dependent kinase 1 (Cdk1)
autoamplification loop, 87–89
cyclin-B amplification loop, 87, 88
master regulator, cell cycle progression,
87, 88
Cytoplasm rearrangements, 389
Cytoplasmic factors, 504
Cytoplasmic polyadenylation element (CPE),
103, 501
Cytoplasmic polyadenylation element-binding
protein (CPEB), 103
Cytoskeleton, 185, 193–194
basolateral membrane formation, 149–150
blastocoel formation, 151, 152
FMA reorganization, 150
microtubule-dependent exocytosis,
150–151
protrusive activity, 151

D
Destruction box (D-box), 89
Developmental Hourglass model
bioinformatics analysis, 314
description, 313, 314
extraembryonic yolk, 315
morphology and gene expression, 315
phylotypic stage, 313
Dicer isoform, 499
Dicer-deficient zebrafish oocytes, 497
DNA methylation
active, 516
CpG, 515
DNMT3 family, 515
early development, nonmammalian
vertebrates, 516–517
epigenetic mark, 515
genome-wide demethylation, 516
IAP, 516
loss of maternal Tet3, 516
maintained, 515

Index
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