Respiratory Treatment and Prevention (Advances in Experimental Medicine and Biology)

reported from Thailand (Table5). Patients with-
out malaria had more comorbidities (Table6).
Most of the patients with malaria used the
antimalarials atovaquone/proguanil and meflo-
quine (Table7). Five male patients (33.3 %,
95 % CI, 0.1–0.6) with malaria and four patients

(10.5 %, 95 % CI, 0.008–0.2; one female) with-

out malaria had used antimalarial chemoprophy-

laxis. Two of those patients (13.3 %, 95 % CI,

0.0–0.3) had discontinued malaria prophylaxis

prematurely due to intolerance. There were no

deaths in either group.

30

25

20

15

10

5

0

2004 2005 2006 2007 2008

Years

Prevalence of malaria (%) of cases) 2009 2010 2011 2012

Fig. 1 Time trends in the
prevalence of imported
malaria to the province of
Saarland, Germany in the
period of 2004–2012.
Percentage of malaria cases
in consecutive year out of
the total of 15 cases

Table 2 Types and species of malaria brought over from long haul destinations to Homburg, Germany, from 2004
to 2012

Type of malaria Patients with malaria (n¼15) (%) p-value 95 % CI
Malaria tropica 11 (73.3) <0.0001 0.50–0.90
Quartan malaria 2 (13.3) 0.667 0.04–0.40
Tertian malaria 2 (13.3) 0.667 0.04–0.40
Plasmodium falciparum 11 (73.3) <0.0001 0.50–0.90
Plasmodium vivax 0 0.197 0.00–0.20
Plasmodium ovale 2 (13.3) 0.667 0.04–0.40
Plasmodium malariae 1 (6.7) 0.670 0.01–0.30
Mixed-species
Plasmodium falciparum

• Plasmodium malariae 1 (6.7) 0.670 0.01–0.30
  CIconfidence interval

Table 3 Comparison of laboratory values between patients with and without malaria

Malaria (n¼15) No malaria (n¼38) p-value

Hemoglobin (14–18 g/dL)
SD 13.0
4.2 17.7
20.3 0.400

Hematocrit (41–53 %)
SD 38.3
12.4 41.3
6.0 0.247

Leukocyte count (4000–10,000/μL)
SD 5478 
 2056 6434 
 2301 0.179

Platelet (140,000–400,000/μL)
SD 137,571
101,143 189,684
73,953 0.047

CRP (<6.0 mg/L)
SD 76.4
75.9 34.1
44.6 0.019

Creatinine (0.7–1.2 mg/dL)
SD 0.8
0.3 1.1
0.7 0.263

Glucose (55–110 mg/dL)
SD 110 
 46 103 
 33 0.525

Bilirubin (0.1–1.0 mg/dL)
SD 1.7
2.2 1.5
4.2 0.863

Data are means
SD;CRPC-reactive protein

40 J. Yayan and K. Rasche