Respiratory Treatment and Prevention (Advances in Experimental Medicine and Biology)

Advs Exp. Medicine, Biology - Neuroscience and Respiration (2016) 27: 73–80
DOI 10.1007/5584_2016_43
#Springer International Publishing Switzerland 2017
Published online: 13 July 2016

Acute Response to Cigarette Smoking

Assessed in Exhaled Breath Condensate

in Patients with Chronic Obstructive

Pulmonary Disease and Healthy Smokers

M. Maskey-Warze ̨ chowska, P. Nejman-Gryz, K. Osinka, P. Lis,

K. Malesa, K. Go ́rska, and R. Krenke

Abstract

The effect of acute exposure to cigarette smoke (CS) on the respiratory

system has been less extensively studied than the long term effects of

smoking. The aim of the present study was to evaluate the acute response

to CS in smokers suffering from chronic obstructive pulmonary disease

(COPD) and in healthy smokers. Nineteen stable COPD patients and

19 young healthy smokers were enrolled. Tumor necrosis factor alpha

(TNF-α), IL-1β, and malondialdehyde (MDA) were measured in exhaled

breath condensate (EBC) before and 60 min after smoking a cigarette.

When pre- and post-CS levels of the evaluated biomarkers were com-

pared, no differences were found in either group. However, the post-CS

MDA was significantly greater in healthy smokers than that in COPD

patients; 20.41 vs.16.81 nmol/L, p¼0.01, respectively. Post-CS TNF-α

correlated inversely with FEV 1 /FVC in healthy smokers. We conclude

that CS does not acutely increase the EBC concentration of the inflamma-

tory markers either in COPD patients or healthy smokers. The short term

CS-induced oxidative stress is higher in young smokers than in COPD

patients, which what may indicate a higher susceptibility to CS content of

the former.

Keywords

Airway obstruction • Inflammation • Malondialdehyde • Smoking •

Tumor necrosis factor alpha

M. Maskey-Warze ̨chowska, P. Nejman-Gryz,
K. Go ́rska (*), and R. Krenke
Department of Internal Medicine, Pneumology and
Allergology, Medical University of Warsaw, 1A
Banacha, 02-097 Warsaw, Poland
e-mail:[email protected]

K. Osinka, P. Lis, and K. Malesa

Student Scientific Association ‘Alveolus’, Department of

Internal Medicine, Pneumology and Allergology, Medical

University of Warsaw, Warsaw, Poland

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