Cysteine Modification 45
Beck C, Wollmuth LP, Seeburg PH, Sakmann B, Kuner T (1999) NMDAR channel segments
forming the extracellular vestibule inferred from the accessibility of substituted cysteines. Neu-
ron 22(3):559–570
Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA (2002) Cation-pi
interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine recep-
tors: the anomalous binding properties of nicotine. Biochemistry 41(32):10262–10269
Beene DL, Price KL, Lester HA, Dougherty DA, Lummis SC (2004) Tyrosine residues that control
binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid
mutagenesis. J Neurosci 24(41):9097–9104. doi:10.1523/JNEUROSCI.2429-04.2004
Bera AK, Chatav M, Akabas MH (2002) GABA(A) receptor M2-M3 loop secondary structure
and changes in accessibility during channel gating. J Biol Chem 277(45):43002–43010.
doi:10.1074/jbc.M206321200 [doi]
Berliner LJ (1983) The spin-label approach to labeling membrane protein sulfhydryl groups. Ann
N Y Acad Sci 414:153–161
Blaustein RO (2002) Kinetics of tethering quaternary ammonium compounds to K(+) channels. J
Gen Physiol 120(2):203–216
Blaustein RO, Cole PA, Williams C, Miller C (2000) Tethered blockers as molecular ‘tape mea-
sures’ for a voltage-gated K+ channel. Nat Struct Biol 7(4):309–311. doi:10.1038/74076
Blunck R, Starace DM, Correa AM, Bezanilla F (2004) Detecting rearrangements of shaker and
NaChBac in real-time with fluorescence spectroscopy in patch-clamped mammalian cells. Bio-
phys J 86(6):3966–3980. doi:10.1529/biophysj.103.034512
Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M, Corringer PJ (2009) X-ray
structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature
457(7225):111–114. doi:10.1038/nature07462 [doi]
Boileau AJ, Kucken AM, Evers AR, Czajkowski C (1998) Molecular dissection of benzodiazepine
binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.
Mol Pharmacol 53(2):295–303
Boileau AJ, Evers AR, Davis AF, Czajkowski C (1999) Mapping the agonist binding site of the
GABAA receptor: evidence for a beta-strand. J Neurosci 19(12):4847–4854
Boileau AJ, Newell JG, Czajkowski C (2002) GABA(A) receptor beta 2 Tyr97 and Leu99 line the
GABA-binding site. Insights into mechanisms of agonist and antagonist actions. J Biol Chem
277(4):2931–2937. doi:10.1074/jbc.M109334200 M109334200 [pii]
Bormann J, Hamill OP, Sakmann B (1987) Mechanism of anion permeation through channels
gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol
385:243–286
Boyer PD (1954) Spectrophotometric study of the reaction of protein sulfhydryl groups with or-
ganic mercurials. J Am Chem Soc 76(17):4331–4337
Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK (2001)
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic
receptors. Nature 411(6835):269–276. doi:10.1038/35077011
Brown KA, Howell EE, Kraut J (1993) Long-range structural effects in a second-site revertant of a
mutant dihydrofolate reductase. Proc Natl Acad Sci U S A 90(24):11753–11756
Careaga CL, Falke JJ (1992a) Structure and dynamics of Escherichia coli chemosensory receptors.
Engineered sulfhydryl studies. Biophys J 62(1):209–216. discussion 217—209
Careaga CL, Falke JJ (1992b) Thermal motions of surface alpha-helices in the D-galactose che-
mosensory receptor. Detection by disulfide trapping. J Mol Biol 226(4):1219–1235. doi:0022-
2836(92)91063-U [pii]
Careaga CL, Sutherland J, Sabeti J, Falke JJ (1995) Large amplitude twisting motions of an inter-
domain hinge: a disulfide trapping study of the galactose-glucose binding protein. Biochemis-
try 34(9):3048–3055
Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK (2004) Nicotine
and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal
structures. Neuron 41(6):907–914. doi:S0896627304001151 [pii]