76 M. Priest and F. Bezanilla
Wang Q, Lynch JW (2011) Activation and desensitization induce distinct conformational chang-
es at the extracellular-transmembrane domain interface of the glycine receptor. J Biol Chem
286:38814–38824
Wang Q, Lynch JW (2012) A comparison of glycine- and ivermectin-mediated conformational
changes in the glycine receptor ligand-binding domain. Int J Biochem Cell Biol 44:335–340
Wang Q, Pless SA, Lynch JW (2010) Ligand- and subunit-specific conformational changes in the
ligand-binding domain and the TM2-TM3 linker of α1 β2 γ2 GABAA receptors. J Biol Chem
285:40373–40386
Wang Y, Liu Y, Deberg HA, Nomura T, Hoffman MT, Rohde PR, Schulten K, Martinac B, Selvin
PR (2014) Single molecule FRET reveals pore size and opening mechanism of a mechano-
sensitive ion channel. eLife 3:e01834
West JW, Patton DE, Scheuer T, Wang Y, Goldin AL, Catterall WA (1992) A cluster of hydrophobic
amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A
89:10910–10914
Yang N, Horn R (1995) Evidence for voltage-dependent S4 movement in sodium channels. Neu-
ron 15:213–218
Yang N, George AL Jr, Horn R (1996) Molecular basis of charge movement in voltage-gated so-
dium channels. Neuron 16:113–122
Yang F, Cui Y, Wang K, Zheng J (2010) Thermosensitive TRP channel pore turret is part of the
temperature activation pathway. Proc Natl Acad Sci U S A 107:7083–7088
Yang F, Ma L, Cao X, Wang K, Zheng J (2014) Divalent cations activate TRPV1 through promot-
ing conformational change of the extracellular region. J Gen Physiol 143:91–103
Zaydman MA, Silva JR, Delaloye K, Li Y, Liang H, Larsson HP, Shi J, Cui J (2013) Kv7.1 ion
channels require a lipid to couple voltage sensing to pore opening. Proc Natl Acad Sci U S A
110:13180–13185
Zhang J, Xue F, Chang Y (2009) Agonist- and antagonist-induced conformational changes of loop
F and their contributions to the r1 GABA receptor function. J Physiol 587:139–153
Zheng J, Zagotta WN (2000) Gating rearrangements in cyclic nucleotide-gated channels revealed
by patch-clamp fluorometry. Neuron 28:369–374