Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

7.1 Nitrosylation/Nitration in the Active Center

• More information about this series at http://www.springer.com/series/


• 1 Background Contents


• 1.1 A Brief Story About Discovery on the Pleiotropic Use of ART.


• 1.2 A Uniform NO Threshold Theory in Disease and Health


• 1.3 The Purpose of Writing the Book


• References


• 2 NO and ART


• 2.1 NO and NOS


• 2.1.1 Production of NO in Organism-Dependent Manners


• 2.1.2 NO’s Medical Use: From Nitroglycerin to Viagra


• and Pathological Views on NO 2.1.3 A “Double-Edged Sword”: Physiological


• 2.1.4 Conclusions


• 2.2 ART and Derivatives


• 2.2.1 The History of ART Discovery.


• and Engineered Microbes 2.2.2 Production of ART in Transgenic Plants


• Concerns of ART 2.2.3 The Pharmaceutical Values and Toxicological


• 2.2.4 The Plausible Mechanisms of ART’s Actions


• 2.2.5 Conclusions


• 2.3 Interactions of Heme with NO and ART


• 2.3.1 Activation of GC by the NO-Heme Interaction


• 2.3.2 Inhibition of COX by the NO-Heme Interaction


• 2.3.3 Conjugation of ART with Heme


• 2.3.4 Conclusions


• References


• 3 ART for Antitumor x Contents


• 3.1 An Overview on Tumor and Antitumor


• of Tumor Cells to Chemotherapeutics 3.2 ART Diminishes NO-Conferred Anticytotoxicity


• 3.2.1 Purposes and Significance


• 3.2.2 Results and Analysis


• 3.2.3 Discussion


• 3.2.4 Conclusions


• 3.3 Pro-oxidant Agents Synergize ART in Killing Tumor Cells


• 3.3.1 Purposes and Significance


• 3.3.2 Results and Analysis


• 3.3.3 Discussion


• 3.3.4 Conclusions


• References


• 4 ART for Antibacterial Infection


• 4.1 An Overview on Bacterial Infection and Antibacterial Infection


• Bacterial Antibiotic Tolerance 4.2 In Vitro Examination for ART Suppressing NO-Conveyed


• 4.2.1 Purposes and Significance


• 4.2.2 Results and Analysis


• 4.2.3 Discussion


• 4.2.4 Conclusions


• Against Bacterial Infection 4.3 In Vivo Evaluation on ART as a Synergist of Antibiotics


• 4.3.1 Proposes and Significance


• 4.3.2 Results and Analysis


• 4.3.3 Discussion


• 4.3.4 Conclusions


• References


• 5 ART for Anti-inflammation


• 5.1 An Overview on Synovitis and Antisynovitis


• 5.2 ART Mitigates Bacteria/Collagen-Induced Synovitis


• 5.2.1 Purposes and Significance


• 5.2.2 Results and Analysis


• 5.2.3 Discussion


• 5.2.4 Conclusions


• 5.3 ART Alleviates Adjuvant/LPS-Induced Synovitis


• 5.3.1 Purposes and Significance


• 5.3.2 Results and Analysis


• 5.3.3 Discussion


• 5.3.4 Conclusions


• References


• 6 ART for Antiaging Contents xi


• 6.1 An Overview on Aging and Antiaging


• 6.2 ART Extends Yeast Lifespan via NO Signaling


• 6.2.1 Purposes and Significance


• 6.2.2 Results and Analysis


• 6.2.3 Discussion


• 6.2.4 Conclusions


• 6.3 ART as a NO Mimetic Compromises Mouse Telomere Shortening


• 6.3.1 Purposes and Significance


• 6.3.2 Results and Analysis


• 6.3.3 Discussion


• 6.3.4 Conclusions


• References


• 7 Prospective


• of Aging-Related Disorders? of Proteins: A Universal Initiator


• Consequence of Obesity? 7.2 Low-Grade Inflammation as an Essential


• on Tumorigenesis/Carcinogenesis? 7.3 The Origin of CSC: Next Breakthrough


• References