Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

(Darren Dugan) #1

126 7 Prospective


Shimizu I, Aprahamin T, Kikuchi R, Shimizu A, Papanicolaou KN, MacLauchlan S, Maruyama
S, Walsh K (2014) Vascular rarefaction mediates whitening of brown fat in obesity. J Clin
Invest 124:2099–2112
Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y,
Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL,
Parker TG, Schneider MD, Finkel T, Verma S (2011) BRCA1 is an essential regulator of
heart function and survival following myocardial infarction. Nat Commun 2:593
Suh SH, Kim KW (2011) Diabetes and cancer: is diabetes causally related to cancer? Diab
Metab J 35:193–198
Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto
T, Mochizuki H, Sakoda S, Nakatsuji Y (2015) Dietary yeasts reduce inflammation in central
nerve system via microflora. Ann Clin Transl Neurol 2:56–66
Taubes G (2012a) Unreveling the obesity-cancer connection. Science 335:28–32
Taubes G (2012b) Cancer prevention with a diabetes pill? Science 335:29
Tsai CY, Peh MT, Feng W, Dymock BW, Moore PK (2015) Hydrogen sulfide promotes adipo-
genesis in 3T3L1 cells. PLoS ONE 10:e0119511
Tsuchiya K, Sakai H, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y (2007) Chronic blockade of
nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced
obese mice. J Biol Chem 148:4548–4556
Veit C, Genze F, Menke A, Hoeffert S, Gress TM, Gierschik P, Giehl K (2004) Activation of
phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial
cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma
cells. Cancer Res 64:5291–5300
Vermeiren J, Van de Wiele T, Van Nieuwenhuyse G, Boeckx P, Verstraete W, Boon N (2012)
Sulfide- and nitrite-dependent nitric oxide production in the intestinal tract. Microb
Biotechnol 5:379–387
Wang F, Tu T, Huang GH, Cai D, Liang XL, Su HY, Zhu ZJ, Li DL, Yang Y, Shen PH, Mao RF,
Yu L, Zhao MM, Li QY (2015) Gut microbiota community and its assembly associated with
age and diet in Chinese centenarians. J Microbiol Biotechnol (Epub ahead of print)
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity
is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW, Mitchell JB (1998) The multifaceted
roles of nitric oxide in cancer. Carcinogenesis 19:711–721
Wu P, Bao F, Zheng Q, Xiao N, Wang DT, Zeng QP (2012) Artemisinin and rapamycin compro-
mise nitric oxide-driven and hypoxia-triggered acute articular synovitis in mice. Sci Sin Vitae
42:724–738
Yermilov V, Rubio J, Ohshima H (1995) Formation of 8-nitroguanine in DNA treated with per-
oxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Lett 376:207–210
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oydomari S, Iwakura Y, Oshima K, Morita
H, Honda H, Ishikawa Y, Hara E, Ohtani N (2013) Obesity-induced gut microbial metabolite
promotes liver cancer through senescence secretome. Nature 499:97–101
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoeson SE (2001) Reversal of
obesity- and diet-induced insulin resistance with salicylate or targeted disruption of Ikkbeta.
Science 293:1673–1677
Zeng QP (2013) S-Nitrosylation-impaired autophagy: an alternative mechanism underlying
aging? PeerJ PrePrints 1:e121v1
Zingarelli B, O’Connor M, Wong H, Salzman AL, Szabo C (1996) Peroxynitrite-mediated DNA
strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cel-
lular energy depletion in macrophages stimulated with bacterial liposaccharide. J Immunol
156:350–358

Free download pdf