39
Efferth T (2005) Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy. Drug Resist
Updates 8:85–97
Efferth T (2006) Molecular pharmacology and pharmacogenomics of artemisinin and its deriva-
tives in cancer cells. Curr Drug Targ 7:407–421
Efferth T, Oesch F (2004) Oxidative stress response of tumor cells: microarray-based comparison
between artemisinins and anthracyclines. Biochem Pharmacol 68:3–10
Efferth T, Briehl MM, Tome ME (2003) Role of antioxidant genes for the activity of artemisinin
against tumor cells. Int J Oncol 23:1231–1235
Gusarov I, Nudler E (2005) NO-mediated cytoprotection: instant adaptation to oxidative stress in
bacteria. Proc Natl Acad Sci USA 102:13855–13860
Gusarov I, Shatalin K, Starodubtseva M, Nudler E (2009) Endogenous NO protects bacteria
against a wide spectrum of antibiotics. Science 325:1380–1384
Jang TJ, Kim DK (2002) Inducible nitric oxide synthase expression of tumor and stromal cells
is associated with the progression of 7,12-dimethylbenz[a]anthracene-induced rat mammary
tumors. Cancer Lett 182:121–126
Konkimalla VB, Blunder M, Korn B, Soomro SA, Jansen H, Chang W, Posner GH, Bauer R,
Efferth T (2008) Effect of artemisinins and other endoperoxides on nitric oxide-related sign-
aling pathway in RAW 264.7 mouse macrophage cells. Nitric Oxide 19:184–191
Krishna S, Bustamante L, Haynes RK, Staines HM (2008) Artemisinins: their growing impor-
tance in medicine. Trends Pharmacol Sci 29:520–527
Kwok JC, Richardson DR (2002) The iron metabolism of neoplastic cells: alterations that facili-
tate proliferation? Crit Rev Oncol Hemat 42:65–78
Lai H, Singh NP (2001) Selective cancer cell cytotoxicity from exposure to dihydroartemisinin
and holotransferrin. Life Sci 70:49
Lind MJ (2008) Principles of cytotoxic chemotherapy. Medicine 36:19–23
Meshnick SR, Tsang TW, Lin FB, Pan HZ, Chang CN, Kuypers F, Chiu D, Lubin B (1989)
Activated oxygen mediates the antimalarial activity of qinghaosu. Prog Clin Biol Res 313:95
Meshnick SR, Thomas A, Ranz A, Xu CM, Pan HZ (1991) Artemisinin (qinghaosu): the role of
intracellular hemin in its mechanism of antimalarial action. Mol Biochem Parasit 49:181–189
O’Neill PM, Barton VE, Ward SA (2010) The molecular mechanism of action of artemisinin—
the debate continues. Molecules 15:1705–1721
Ridnour LA, Thomas DD, Donzelli S, Espey MG, Roberts DD, Wink DA, Isenberg JS
(2006) The biphasic nature of nitric oxide responses in tumor biology. Antioxid Redox Signal
8:1329–1337
Senok AC, Nelson EAS, Li K, Oppenheimer SJ (1997) Thalassaemia trait, red blood cell age and
oxidant stress: effects on Plasmodium faciparum growth and sensitivity to artemisinin. Trans
Soc Trop Med Hyg 91:585
Simizu S, Takada M, Umezawa K, Imoto M (1998) Requirement of caspase-3-(like) protease-
mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. J
Boil Chem 273:26900–26907
Uhlemann AC, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M,
Lee A, Brady L, Haynes RK, Krishna S (2005) A single amino acid residue can determine
the sensitivity of SERCAs to artemisinin. Nat Struct Mol Biol 12:628–629
Wink DA, Hanbauer I, Krishna MC, DeGraff W, Gamson J, Mitchell JB (1993) Nitric oxide pro-
tects against cellular damage and cytotoxicity from reactive oxygen species. Proc Natl Acad
Sci USA 90:9813–9817
Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB (1995) Nitric oxide (NO)
protects against cellular damage by reactive oxygen species. Toxicol Lett 82–83:221-226
Woerdenbag HJ, Moskal TA, Pras N, Malingre TM, Elferaly FS, Kampinga HH, Konings AWT
(1993) Cytotoxicity of artemisinin-related endoperoxides to ehrlich ascites cancer-cells. J
Nat Prod 56:849–856
Zhang SM, Gerhard GS (2009) Heme mediates cytotoxicity from artemisinin and serves as a
general anti-proliferation target. PLoS ONE 4:7472
References