Harmonisation of Regulatory Oversight in Biotechnology Safety Assessment of Transgenic Organisms in the Environment, Volume 5..

INTRODUCTION TO THE BIOSAFETY CONSENSUS DOCUMENTS – 19 in the first document developed jointly by the two bodies, the “Consensus ...

20 – INTRODUCTION TO THE BIOSAFETY CONSENSUS DOCUMENTS Annex: OECD biosafety principles and concepts developed prior to the Work ...

INTRODUCTION TO THE BIOSAFETY CONSENSUS DOCUMENTS – 21 reaffirmed that, “safety in biotechnology is achieved by the appropriate ...

22 – INTRODUCTION TO THE BIOSAFETY CONSENSUS DOCUMENTS the presence of related (and sexually compatible) plants in the surround ...

INTRODUCTION TO THE BIOSAFETY CONSENSUS DOCUMENTS – 23 OECD (2006b), Safety Assessment of Transgenic Organisms: OECD Consensus D ...

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PART I: MICRO-ORGANISMS – 25 Part I: Micro-organisms ...

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I.1. BACTERIA: PATHOGENICITY FACTORS – 27 Chapter 1. Bacteria: Pathogenicity factors This chapter provides guidance on topics an ...

28 – I.1. BACTERIA: PATHOGENICITY FACTORS General considerations for bacterial pathogenicity This chapter provides guidance on t ...

I.1. BACTERIA: PATHOGENICITY FACTORS – 29 Pathogenicity is a multifactorial process which depends on the immune status of the ho ...

30 – I.1. BACTERIA: PATHOGENICITY FACTORS behaviour may establish a foothold in this microbial ecosystem. Once established, othe ...

I.1. BACTERIA: PATHOGENICITY FACTORS – 31 For practical reasons, also in regulatory practice, a distinction is drawn between bac ...

32 – I.1. BACTERIA: PATHOGENICITY FACTORS to be non-pathogens, because they rarely or never cause human disease. However, it sho ...

I.1. BACTERIA: PATHOGENICITY FACTORS – 33 most cases the bacterium producing the toxin has to be established within the host in ...

34 – I.1. BACTERIA: PATHOGENICITY FACTORS an action that leads to the creation of intermolecular bonds requiring a certain amoun ...

I.1. BACTERIA: PATHOGENICITY FACTORS – 35 Table 1.1. Examples of specific bacterial adherence to host cell surfaces Bacterium/di ...

36 – I.1. BACTERIA: PATHOGENICITY FACTORS Table 1.1. Examples of specific bacterial adherence to host cell surfaces (cont.) Bact ...

I.1. BACTERIA: PATHOGENICITY FACTORS – 37 While not an all-inclusive list, Table 1.1 gives examples of specific attachments of m ...

38 – I.1. BACTERIA: PATHOGENICITY FACTORS tip proteins can significantly alter the tropism of the bacteria for a specific recept ...