© Springer Nature Singapore Pte Ltd. 2017 181
J. Xiao (ed.), Exercise for Cardiovascular Disease Prevention and Treatment,
Advances in Experimental Medicine and Biology 999,
DOI 10.1007/978-981-10-4307-9_11
Chapter 11
Experimental Evidences Supporting
the Benefits of Exercise Training
in Heart Failure
Marcelo H.A. Ichige, Marcelo G. Pereira, Patrícia C. Brum,
and Lisete C. Michelini
Abstract Heart Failure (HF), a common end point for many cardiovascular dis-
eases, is a syndrome with a very poor prognosis. Although clinical trials in HF have
achieved important outcomes in reducing mortality, little is known about functional
mechanisms conditioning health improvement in HF patients. In parallel with clini-
cal studies, basic science has been providing important discoveries to understand
the mechanisms underlying the pathophysiology of HF, as well as to identify poten-
tial targets for the treatment of this syndrome. In spite of being the end-point of
cardiovascular derangements caused by different etiologies, autonomic dysfunc-
tion, sympathetic hyperactivity, oxidative stress, inflammation and hormonal
activation are common factors involved in the progression of this syndrome.
M.H.A. Ichige
Department of Physiology & Biophysics, Institute of Biomedical Sciences,
University of Sao Paulo, Sao Paulo, Brazil
e-mail: [email protected]
M.G. Pereira
Department of Biodynamics of Human Body Movement, School of Physical Education
and Sport, University of Sao Paulo, Sao Paulo, Brazil
e-mail: [email protected]
P.C. Brum (*)
Department of Biodynamics of Human Body Movement, School of Physical Education
and Sport, University of Sao Paulo, Sao Paulo, Brazil
National Institute for Science & Technology - INCT (In)activity & Exercise, CNPq - Niterói (RJ),
Rio de Janeiro, Brazil
e-mail: [email protected]
L.C. Michelini
Department of Physiology & Biophysics, Institute of Biomedical Sciences,
University of Sao Paulo, Sao Paulo, Brazil
National Institute for Science & Technology - INCT (In)activity & Exercise, CNPq - Niterói (RJ),
Rio de Janeiro, Brazil
e-mail: [email protected]