247
combination can affect catecholamine regulation that when inappropriately managed,
can result in improper calcium handling leading to negative exercise response. Thus,
an exercise intervention and its effect must be viewed contextually and more studies
focusing on the adverse effects must be welcomed in the future to obtain a complete
picture. At the same time, we do not propose that an incomplete picture of redox
status as a definite detractor of existing intervention protocol. Considerations to these
subtle yet important mechanistic details could confer better outcome with respect to
cardiovascular adaptations and avoid any possible risks in the asymptomatic aged
group. Nonetheless, to put more prosaically and simply, “Manage Nrf2, Balance the
redox, Exercise smarter, Build a healthy heart”.
Acknowledgement This book chapter includes various studies that were supported by funding
from NHLBI (HL118067), NIA (AG042860), the AHA (BGIA 0865015F), University of Utah
Center for Aging (Pilot grant#2009), and the start-up funds from the Division of Cardiovascular
Medicine/ Department of Medicine, University of Utah and Department of Pathology (3115851.0
00.213115851.392300000.0000 for NSR), University of Alabama at Birmingham, AL.
Authors’ deeply thank Drs. Gobinath Shanmugam and Rajesh Kumar Radhakrishnan for their
assistance with graphical art work, literature collection and citing bibliography using end-note.
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13 Cardiac Agingfi– Bene ts offiExercise, Nrf2 Activation andfiAntioxidant Signaling