Safdar A, de Beer J, Tarnopolsky MA (2010) Dysfunctional Nrf2-Keap1 redox signaling in
skeletal muscle of the sedentary old. Free Radic Biol Med 49(10):1487–1493
Kumar RR, Narasimhan M, Shanmugam G et al (2016) Abrogation of Nrf2 impairs antioxi-
dant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.
J Transl Med 14(1):86
Narasimhan M, Rajasekaran NS (2016) Exercise, Nrf2 and antioxidant signaling in cardiac
aging. Front Physiol 7:241
Stratton JR, Levy WC, Cerqueira MD et al (1994) Cardiovascular responses to exercise.
Effects of aging and exercise training in healthy men. Circulation 89(4):1648–1655
Wang S, Li Y, Song X et al (2015) Febuxostat pretreatment attenuates myocardial ischemia/
reperfusion injury via mitochondrial apoptosis. J Transl Med 13:209
Belardinelli R, Georgiou D, Cianci G et al (1999) Randomized, controlled trial of long-term
moderate exercise training in chronic heart failure. Circulation 99(9):1173–1182
Barboza CA, Rocha LY, Mostarda CT et al (2013) Ventricular and autonomic benefits of exer-
cise training persist after detraining in infarcted rats. Eur J Appl Physiol 113(5):1137–1146
Chicco AJ, Hydock DS, Schneider CM et al (2006) Low-intensity exercise training during
doxorubicin treatment protects against cardiotoxicity. J Appl Physiol (1985) 100(2):519–527
Bocalini DS, Beutel A, Bergamaschi CT et al (2014) Treadmill exercise training prevents
myocardial mechanical dysfunction induced by androgenic-anabolic steroid treatment in rats.
PLoS One 9(2):e87106
Gregg EW, Gerzoff RB, Caspersen CJ et al (2003) Relationship of walking to mortality
among US adults with diabetes. Arch Intern Med 163(12):1440–1447
Brassard P, Legault S, Garneau C et al (2007) Normalization of diastolic dysfunction in type
2 diabetics after exercise training. Med Sci Sports Exerc 39(11):1896–1901
Tanasescu M, Leitzmann MF, Rimm EB et al (2003) Physical activity in relation to car-
diovascular disease and total mortality among men with type 2 diabetes. Circulation
107(19):2435–2439
Xu X, Zhao W, Wan W et al (2010) Exercise training combined with angiotensin II recep-
tor blockade reduces oxidative stress after myocardial infarction in rats. Exp Physiol
95(10):1008–1015
Bean JF, Vora A, Frontera WR (2004) Benefits of exercise for community-dwelling older
adults. Arch Phys Med Rehabil 85(3):31–42
Deschenes MR, Ogilvie RW (1999) Exercise stimulates neovascularization in occluded mus-
cle without affecting bFGF content. Med Sci Sports Exerc 31(11):1599–1604
Whyte JJ, Laughlin MH (2010) The effects of acute and chronic exercise on the vasculature.
Acta Physiol 199(4):441–450
Padilla J, Simmons GH, Bender SB et al (2011) Vascular effects of exercise: endothelial
adaptations beyond active muscle beds. Physiology 26(3):132–145
Kim TH, Hur EG, Kang SJ et al (2011) NRF2 blockade suppresses colon tumor angiogenesis
by inhibiting hypoxia-induced activation of HIF-1alpha. Cancer Res 71(6):2260–2275
Zhang Z, Wang Q, Ma J et al (2013) Reactive oxygen species regulate FSH-induced expres-
sion of vascular endothelial growth factor via Nrf2 and HIF1alpha signaling in human epithe-
lial ovarian cancer. Oncol Rep 29(4):1429–1434
Lupien SJ, de Leon M, de Santi S et al (1998) Cortisol levels during human aging predict
hippocampal atrophy and memory deficits. Nat Neurosci 1(1):69–73
Safdar A, Bourgeois JM, Ogborn DI et al (2011) Endurance exercise rescues progeroid aging
and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad
Sci U S A 108(10):4135–4140
Seals DR, Hagberg JM, Hurley BF et al (1984) Effects of endurance training on glucose toler-
ance and plasma lipid levels in older men and women. JAMA 252(5):645–649
