van de Veerdonk MC, Kind T, Marcus JT et al (2011) Progressive right ventricular dysfunction
in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol
58(24):2511–2519
Hopkins WE, Waggoner AD (2002) Severe pulmonary hypertension without right ventricular
failure: the unique hearts of patients with Eisenmenger syndrome. Am J Cardiol 89(1):34–38
Warnes CA (2009) Adult congenital heart disease: importance of the right ventricle. J Am Coll
Cardiol 54(21):1903–1910
Members WC, McLaughlin VV, Archer SL et al (2009) ACCF/AHA 2009 expert consen-
sus document on pulmonary hypertension: a report of the American College of Cardiology
Foundation task force on expert consensus documents and the American Heart Association:
developed in collaboration with the American College of Chest Physicians, American Thoracic
Society, Inc., and the Pulmonary Hypertension Association. Circulation 119(16):2250–2294
Haddad F, Doyle R, Murphy DJ et al (2008) Right ventricular function in cardiovascular
disease, part II: pathophysiology, clinical importance, and management of right ventricular
failure. Circulation 117(13):1717–1731
Bogaard HJ, Natarajan R, Henderson SC et al (2009) Chronic pulmonary artery pressure ele-
vation is insufficient to explain right heart failure. Circulation 120(20):1951–1960
Handoko ML, de Man FS, Allaart CP et al (2010) Perspectives on novel therapeutic strate-
gies for right heart failure in pulmonary arterial hypertension: lessons from the left heart. Eur
Respir Rev 19(115):72–82
Vonk Noordegraaf A, Westerhof BE, Westerhof N (2017) The relationship between the right
ventricle and its load in pulmonary hypertension. J Am Coll Cardiol 69(2):236–243
Voelkel NF, Gomez-Arroyo J, Abbate A et al (2013) Mechanisms of right heart failure-a work
in progress and a plea for failure prevention. Pulm Circ 3(1):137–143
Campian ME, Hardziyenka M, de Bruin K et al (2010) Early inflammatory response during the
development of right ventricular heart failure in a rat model. Eur J Heart Fail 12(7):653–658
Soon E, Holmes AM, Treacy CM et al (2010) Elevated levels of inflammatory cytokines
predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation
122(9):920–927
Lowes BD, Minobe W, Abraham WT et al (1997) Changes in gene expression in the intact
human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricu-
lar myocardium. J Clin Invest 100(9):2315–2324
Kogler H, Hartmann O, Leineweber K et al (2003) Mechanical load-dependent regulation of
gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res
93(3):230–237
Correia-Pinto J, Henriques-Coelho T, Roncon-Albuquerque R et al (2009) Time course and
mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced
pulmonary hypertension. Basic Res Cardiol 104(5):535–545
Usui S, Yao A, Hatano M et al (2006) Upregulated neurohumoral factors are associated with
left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary
arterial hypertension. Circ J 70(9):1208–1215
Falcao-Pires I, Goncalves N, Henriques-Coelho T et al (2009) Apelin decreases myocardial
injury and improves right ventricular function in monocrotaline-induced pulmonary hyperten-
sion. Am J Physiol Heart Circ Physiol 296(6):H2007–H2014
Redout EM, van der Toorn A, Zuidwijk MJ et al (2010) Antioxidant treatment attenuates
pulmonary arterial hypertension-induced heart failure. Am J Physiol Heart Circ Physiol
298(3):H1038–H1047
Demarco VG, Whaley-Connell AT, Sowers JR et al (2010) Contribution of oxidative stress to
pulmonary arterial hypertension. World J Cardiol 2(10):316–324
Crosswhite P, Sun Z (2010) Nitric oxide, oxidative stress and inflammation in pulmonary arte-
rial hypertension. J Hypertens 28(2):201–212
Daicho T, Yagi T, Abe Y et al (2009) Possible involvement of mitochondrial energy-producing
ability in the development of right ventricular failure in monocrotaline-induced pulmonary
hypertensive rats. J Pharmacol Sci 111(1):33–43
