141
- Poordad F, Schiff ER, Vierling JM, Landis C, Fontana RJ, Yang R, McPhee F, Hughes EA,
Noviello S, Swenson ES (2016) Daclatasvir with sofosbuvir and ribavirin for hepatitis C
virus infection with advanced cirrhosis or post-liver transplantation recurrence. Hepatology
63:1493–1505 - Hsu CS, Chao YC, Lin HH, Chen DS, Kao JH (2015) Systematic review: impact of interferon-
based therapy on HCV-related hepatocellular carcinoma. Sci Rep 5:9954 - Mesri EA, Feitelson MA, Munger K (2014) Human viral oncogenesis: a cancer hallmarks
analysis. Cell Host Microbe 15:266–282 - Arzumanyan A, Reis HM, Feitelson MA (2013) Pathogenic mechanisms in HBV- and HCV-
associated hepatocellular carcinoma. Nat Rev Cancer 13:123–135 - Mitchell JK, Lemon SM, McGivern DR (2015) How do persistent infections with hepatitis C
virus cause liver cancer? Curr Opin Virol 14:101–108 - Giannelli G, Koudelkova P, Dituri F, Mikulits W (2016) Role of epithelial to mesenchymal
transition in hepatocellular carcinoma. J hepatol 65:798 - Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in
development and disease. Cell 139:871–890 - Friedman SL (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology 134:1655–1669
- Liu J, Ding X, Tang J, Cao Y, Hu P, Zhou F, Shan X, Cai X, Chen Q, Ling N, Zhang B, Bi
Y, Chen K, Ren H, Huang A, He TC, Tang N (2011) Enhancement of canonical Wnt/beta-
catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carci-
noma cells. PLoS One 6:e27496 - Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim H, Jung G, Choi KY, Hwang SB (2009)
Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis
C virus-induced liver pathogenesis. J Hepatol 51:853–864 - Street A, Macdonald A, Crowder K, Harris M (2004) The hepatitis C virus NS5A protein
activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J Biol Chem
279:12232–12241 - Street A, Macdonald A, McCormick C, Harris M (2005) Hepatitis C virus NS5A-mediated
activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and
stimulation of beta-catenin-responsive transcription. J Virol 79:5006–5016 - Munakata T, Liang Y, Kim S, McGivern DR, Huibregtse J, Nomoto A, Lemon SM (2007)
Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein. PLoS
Pathog 3:1335–1347 - Munakata T, Nakamura M, Liang Y, Li K, Lemon SM (2005) Down-regulation of the retino-
blastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
Proc Natl Acad Sci U S A 102:18159–18164 - Higgs MR, Lerat H, Pawlotsky JM (2013) Hepatitis C virus-induced activation of beta-
catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events. Oncogene
32:4683–4693 - Benzoubir N, Lejamtel C, Battaglia S, Testoni B, Benassi B, Gondeau C, Perrin-Cocon L,
Desterke C, Thiers V, Samuel D, Levrero M, Brechot C, Bourgeade MF (2013) HCV core-
mediated activation of latent TGF-beta via thrombospondin drives the crosstalk between
hepatocytes and stromal environment. J Hepatol 59:1160–1168 - Walters KA, Syder AJ, Lederer SL, Diamond DL, Paeper B, Rice CM, Katze MG (2009)
Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apop-
tosis of cultured hepatocytes. PLoS Pathog 5:e1000269 - Kannan RP, Hensley LL, Evers LE, Lemon SM, McGivern DR (2011) Hepatitis C virus
infection causes cell cycle arrest at the level of initiation of mitosis. J Virol 85:7989–8001 - Wang Y, Wang Y, Xu Y, Tong W, Pan T, Li J, Sun S, Shao J, Ding H, Toyoda T, Yuan Z (2011)
Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived
cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP). J Biol Chem
286:26603–26615 - Fischer R, Baumert T, Blum HE (2007) Hepatitis C virus infection and apoptosis. World
J Gastroenterol 13:4865–4872
8 HCV-Associated Cancers