223
- Bounhar Y, Zhang Y, Goodyer CG, LeBlanc A (2001) Prion protein protects human neurons
against Bax-mediated apoptosis. J Biol Chem 276:39145–39149 - Bounhar Y, Mann KK, Roucou X, LeBlanc AC (2006) Prion protein prevents Bax-mediated
cell death in the absence of other Bcl-2 family members in Saccharomyces Cerevisiae. FEMS
Yeast Res 6:1204–1212 - Chieng CK, Say YH (2015) Cellular prion protein contributes to LS 174T colon cancer cell
carcinogenesis by increasing invasiveness and resistance against doxorubicin-induced apop-
tosis. Tumour Biol: J Int Soc Oncodevelopmental Biol Med 36:8107–8120 - Wang JH, Du JP, Li SJ, Zhai LP, Yang XY, Wang ZH, Wu ZT, Han Y (2012) Octarepeat
peptides of prion are essential for multidrug resistance in gastric cancer cells. J Dig Dis
13:143–152 - Meslin F, Conforti R, Mazouni C, Morel N, Tomasic G, Drusch F, Yacoub M, Sabourin JC,
Grassi J, Delaloge S, Mathieu MC, Chouaib S, Andre F, Mehrpour M (2007) Efficacy of adju-
vant chemotherapy according to prion protein expression in patients with estrogen receptor-
negative breast cancer. Annals Oncol: Off J Eur Soc Med Oncol/ESMO 18:1793–1798 - Cashman NR, Loertscher R, Nalbantoglu J, Shaw I, Kascsak RJ, Bolton DC, Bendheim PE
(1990) Cellular isoform of the scrapie agent protein participates in lymphocyte activation.
Cell 61:185–192 - Mabbott NA, Brown KL, Manson J, Bruce ME (1997) T-lymphocyte activation and the cel-
lular form of the prion protein. Immunology 92:161–165 - Pammer J, Weninger W, Tschachler E (1998) Human keratinocytes express cellular prion-
related protein in vitro and during inflammatory skin diseases. Am J Pathol 153:1353–1358 - Konturek PC, Bazela K, Kukharskyy V, Bauer M, Hahn EG, Schuppan D (2005) Helicobacter
pylori upregulates prion protein expression in gastric mucosa: a possible link to prion disease.
World J Gastroenterol 11:7651–7656 - Linden R, Martins VR, Prado MAM, Cammarota M, Izquierdo I, Brentani RR (2008)
Physiology of the prion protein. Physiol Rev 88:673–728 - de Almeida CJG, Chiarini LB, da Silva JP, Silva PMRE, Martins MA, Linden R (2005) The
cellular prion protein modulates phagocytosis and inflammatory response. J Leukoc Biol
77:238–246 - Durig J, Giese A, Schulz-Schaeffer W, Rosenthal C, Schmucker U, Bieschke J, Duhrsen
U, Kretzschmar HA (2000) Differential constitutive and activation-dependent expression of
prion protein in human peripheral blood leucocytes. Brit J Haematol 108:488–496 - Haddon DJ, Hughes MR, Antignano F, Westaway D, Cashman NR, McNagny KM (2009)
Prion protein expression and release by mast cells after activation. J Infect Dis 200:827–831 - Petit CSV, Barreau F, Besnier L, Gandille P, Riveau B, Chateau D, Roy M, Berrebi D, Svrcek
M, Cardot P, Rousset M, Clair C, Thenet S (2012) Requirement of cellular prion protein for
intestinal barrier function and mislocalization in patients with inflammatory bowel disease.
Gastroenterology 143:122–U679 - Martin GR, Keenan CM, Sharkey KA, Jirik FR (2011) Endogenous prion protein attenuates
experimentally induced colitis. Am J Pathol 179:2290–2301 - Mariante RM, Nobrega A, Martins RAP, Areal RB, Bellio M, Linden R (2012)
Neuroimmunoendocrine regulation of the prion protein in neutrophils. J Biol Chem
287:35506–35515 - Ding TJ, Zhou XM, Kouadir M, Shi FS, Yang Y, Liu J, Wang M, Yin XM, Yang LF, Zhao
DM (2013) Cellular prion protein participates in the regulation of inflammatory response
and apoptosis in BV2 microglia during infection with mycobacterium Bovis. J Mol Neurosci
51:118–126 - Walsh KP, Minamide LS, Kane SJ, Shaw AE, Brown DR, Pulford B, Zabel MD, Lambeth JD,
Kuhn TB, Bamburg JR. 2014. Amyloid-beta and proinflammatory cytokines utilize a prion
protein-dependent pathway to activate NADPH oxidase and induce Cofilin-actin rods in hip-
pocampal neurons. PLoS One 9
13 Prion Protein Exacerbates Tumorigenesis