© Springer Nature Singapore Pte Ltd. 2017 253
Q. Cai et al. (eds.), Infectious Agents Associated Cancers: Epidemiology
and Molecular Biology, Advances in Experimental Medicine and Biology 1018,
DOI 10.1007/978-981-10-5765-6_16
Chapter 16
Interplay Between Microenvironmental
Abnormalities and Infectious Agents
in Tumorigenesis
Qing Zhu, Feng Gu, Caixia Zhu, Yuyan Wang, Fang Wei, and Qiliang Cai
Abstract Emerging evidence has shown that the cell of microenvironmental abnor-
malities is a key factor that controls many cellular physiological processes including
cellular communication, homing, proliferation, and survival. Given its central regu-
latory role, it is therefore not surprising that it is widely exploited by infectious
agents for inducing pathogenesis. In the past decade, a number of oncogenic patho-
gens including viruses, bacteria, and parasites are demonstrated to take advantage of
the tumor microenvironmental factors including hypoxia, oxidative stress, and cyto-
kines, to create an extracellular environment more favorable for pathogen survival
and propagation and escape from the host immune surveillance. Here we summa-
rize and highlight the current understanding of the interplay between common
tumor microenvironmental factors and oncogenic pathogens in promoting
tumorigenesis.
Keywords Tumor microenvironment • Pathogen • Oncogenesis
Qing Zhu and Feng Gu equally contributed to this work.
Q. Zhu • F. Gu • C. Zhu • Y. Wang • Q. Cai (*)
Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School
of Basic Medical Sciences, Fudan University, Shanghai 200032, People’s Republic of China
e-mail: [email protected]
F. Wei (*)
ShengYushou Center of Cell Biology and Immunology, School of Life Sciences and
Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China
e-mail: [email protected]