Chromogranins from Cell Biology to Physiology and Biomedicine

72 primitive species such as protozoa and nematodes that contain only a single IP 3 R type. These facts amply suggest that the c ...

73 Despite the seemingly equal contribution of these IP 3 R isoforms to form the IP 3 R/Ca2+ channels, there is relatively littl ...

74 4 Interaction Between the L3-2 Loop and the Near N-Terminal Region Reflecting the pH dependency of the interaction between ch ...

75 the intact CGA and the L3-2 loop peptide is −6.0 ~ −6.9 kcal/mol (Kd, 11–17 μM) at pH 5.5 whereas that between the near N-ter ...

76 5 Physiological Significance of the Chromogranin-IP 3 R Interaction Despite the many similarities in physicochemical properti ...

77 open probability 8- to 16-fold and the mean open time of the channel 24- to 42-fold (Thrower et  al. 2003 ). This IP 3 R/Ca2+ ...

78 7 Effects of CGB Presence in the Cytoplasm and the Nucleus The difference in the interaction property of CGA and CGB appeared ...

79 magnitude of IP 3 -mediated nucleoplasmic Ca2+ releases (Fig. 4B). Although CGA expression in nonsecretory NIH3T3 cells was w ...

80 Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II (2015) Gating machinery of InsP3R channel ...

81 Yoo SH (2010) Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine ...

© Springer International Publishing AG 2017 83 T. Angelone et al. (eds.), Chromogranins: from Cell Biology to Physiology and Bio ...

84 many others. Thus, the identification of factors that regulate vascular homeostasis and angiogenesis, and the elucidation of ...

85 Imbrogno et  al. 2004 ; Corti et  al. 2004 ), inhibits parathyroid hormone secretion (Russell et al. 1994 ), is neurotoxic in ...

86 represents the main mechanism for the transport of molecules in physiological con- ditions, the paracellular transport become ...

87 a mechanism based on heparan sulfate proteoglycans interaction, caveolae endocy- tosis and a PI3K-dependent eNOS phosphorylat ...

88 other in the rat aortic ring (RAR) assay (Bianco et al. 2016 ) suggesting that CgA and its fragments may form a balance of an ...

89 immunoassays unable to discriminate between full-length CgA and fragments, vary within the 0.5–2 nM range, depending on the d ...

90 essential hypertension or in normotensive subjects with a family history of hyper- tension and increased epinephrine secretio ...

91 role on tumor vascular physiology. This may have a potential impact on angiogen- esis, as well as on tumor cell trafficking a ...

92 exogenous CgA can inhibit the in vivo penetration of an anti-Thy1.1 antibody into lymphomas genetically engineered to express ...