Chromogranins from Cell Biology to Physiology and Biomedicine

154 The influence exerted by CST on the Frank-Starling response of both normotensive Wistar Kyoto and hypertensive rat hearts wa ...

155 negative inotropic effects, while coronary pressure was unaffected. The negative effect of Chr was mediated by the AKT/eNOS/ ...

156 Table 1 Main effects exerted by CgA-derived peptides on cardiac contractility and related pathways Peptide Model Force of co ...

157 3 Endothelial-Mediated Effects of VS-1 and CST To investigate the possible role of endothelial-derived mediators in the acti ...

158 do not act directly on cardiomyocytes but, rather, on other cell types present in car- diac tissue, presumably endothelial c ...

159 In a further work from our laboratory, we investigated this pathway also for CST (Fornero et al. 2014 ). To this purpose, we ...

160 membranes, while in the presence of 5  nM CST green fluorescence appeared diffused in the cytosol, as a consequence of Cav1 ...

161 4.1 Histamine The potent vasodilator action of CST in rats has been explained as due to the release of the vasodilator hista ...

162 the key role of endothelial cells in mediating the myocardial actions of CgA-derived peptides. In view of the anti-adrenergi ...

163 suggest a novel cardioprotective role for CST, which appears mainly due to a direct reduction of post-ischemic myocardial da ...

16 4 cardio-suppressive and vasodilator properties of VS-1 and CST have been recently explained as due to a PI3K-dependent-NO re ...

165 Angelone T, Quintieri AM, Pasqua T, Filice E, Cantafio P, Scavello F et al (2015) The NO stimu- lator, Catestatin, improves ...

166 Fornero S, Bassino E, Ramella R, Gallina C, Mahata SK, Tota B et  al (2014) Obligatory role for endothelial heparan sulphate ...

167 Matsuda N, Jesmin S, Takahashi Y, Hatta E, Kobayashi M, Matsuyama K et al (2004) Histamine H1 and H2 receptor gene and prote ...

168 Steiner HJ, Weiler R, Ludescher C, Schmid KW, Winkler H (1990) Chromogranins A and B are co-localized with atrial natriureti ...

© Springer International Publishing AG 2017 169 T. Angelone et al. (eds.), Chromogranins: from Cell Biology to Physiology and Bi ...

170 Abbreviations A/R Anoxia/Reoxygenation Akt Serine/threonine protein kinase AMI Acute Myocardial Infarction BNP Brain Natriur ...

171 1 Introduction Several endogenous cardioprotective factors, including gasotransmitters nitric oxide, hydrogen sulphide and c ...

172 sympatho- adrenal tone and cardiovascular functions. Importantly, CST, VS-1 and Serp also act as cardioprotective agents aga ...

173 The effects of reperfusion injury include (a) vascular and endothelial dysfunc- tion, reduction of nitric oxide (NO) product ...