Chromogranins from Cell Biology to Physiology and Biomedicine

263

processing of, 115
bovine CGs, 51
DV vs. NDV, 52–53
human CGA, endogenous cleavage
sites of, 53
PMNs, 51–52
receptors, 10–11
secretory granule biogenesis
hormone sorting, TGN membrane,
42–43
regulators of, 40–41
structure and expression, 84
Chromogranin B (CgB)
catecholamines exocytosis, 253–255
IP 3 R/Ca2+ channel interaction
(see (Inositol 1,4,5-trisphosphate
receptor (IP 3 R)/Ca2+ channel,
chromogranins A and B))
type-2 diabetes, 44
Chromogranin C. See Secretogranin II (SgII)
Chromogranins (Cgs), 45
hormone aggregation, 41
hypersecretory endocrine pathologies,
43–44
immobile components, 251
physiological roles, 250–251
secretory granule biogenesis
hormone sorting, TGN membrane,
42–43
regulators of, 40–41
structural properties, 40, 41
vesicular components, 251–252
Circular dichroism (CD), 159
Coronary pressure (CP), 116
CST. See Catestatin (CST)
Cyclic AMP response element (CRE), 27
Cytosolic proteins, 43

D
Dense core secretory granules (DCG), 214
Diabetic retinopathy, 89
Diazoxide, 176, 180
Doxorubicin, 91

E
Electropherogram, 205
EM66, 43–44
Endocardial endothelium (EE), 139, 141–143,
152
Endothelial nitric oxide synthase (eNOS),
86–87, 108, 117–118
Endothelin-1 (ET-1), 116, 117

Endothelin-1 A subtype receptor (ETAR),

141–142

Endothelin-1 B subtype receptor (ETBR),

141–142

End-stage renal disease (ESRD), 203

Entherocromaffin cells (ECL), 231

Enzyme immunoassay (EIA), 214

Enzyme-linked immunosorbent assays

(ELISA), 89, 105

Essential hypertension, 43, 44, 90

Ezrin-radixin-moesin binding phosphoprotein

50 (EBP50), 85

F

Fibroblast adhesion, 85

Fibroblast growth factor (FGF)-2, 87, 90

Frank–Starling response, 138, 142–143, 154

Full length chromogranin A, cardio-circulatory

system

intracardiac localization and myocardial

processing, 104–105

normotensive and SHR heart

intracardiac CGA processing, 108–109

myocardial and coronary actions,

106–107

obligatory endothelium-NO

involvement, 107–108

plasma CGA levels, 103–104

region-specific processing-dependent

analysis, 103

SAN overactivation, 101–102

serological determinations, 103

sites of interventions, 110

G

General adaptation syndrome, 101

Glomerular filtration rate (GFR), 203

Glomerular layer (GL), 220

Golgi apparatus, 214, 222

G-protein coupled receptor (GPCR), 31

G-proteins, 11–12

Guanylyl cyclase (GC), 176

H

Half time relaxation (HTR), 116

Heart failure (HF), 28

chronic SAN activation, 102

circulating CgA and fragments, 89

Heparan sulfate proteoglycans (HSPGs),

157, 159

High-mobility group box (HMGB)-1, 86

Index