58
MIC. The comparison was made with the antibiotic or peptide separately at the
same doses. Minocycline has a MIC of 2 μg/ml alone against the S. aureus ATCC
49775, but when it was combined with CTL at a concentration corresponding to
75% of the MIC, the concentration of Minocycline was lowered to 0.5 μg/ml.
Similar data were obtained by the use of the amidated bCTL and Minocycline
against S. aureus and CTL with Voriconazole against C. albicans and C. tropicalis
(Thesis of Menonve Atindehou).
To conclude, these different assays show that bCTL facilitates the effect of anti-
biotic drugs and might allow the decrease of the administered concentrations and
prevent the antibiotic resistance process.
Fig. 5 HPLC chromatograms of bCAT, hCAT and CTL alone or with different bacterial strain
supernatants (ATCC 49775 and ATCC 25923) with (b, d, f) or not (a, c, e) protease inhibitors
(Aslam et al. 2013b)
M.-H. Metz-Boutigue and F. Schneider