- V.A. Bloomfield, D.M. Crothers and J.I. Tinoco (eds), Nucleic Acids Structures, Properties, and
Functions.University Science Books, Sausalito, CA, 2000. - I. Haq, C.B.Z., J.T.C. and C.J.B., Parsing the free energy of drug-DNA Interactions. Meth.
Enzymol., 2000, 323 , 373–405. - I. Haq, C.B.Z. and J.T.C., The interaction of drugs with higher order DNA structures. Meth. Enzymol.,
2001, 340 , 109–149. - I. Jelesarov and H.R. Bosshard, Isothermal titration calorimetry and differential scanning calorimetry
as complementary tools to investigate the energetics of biomolecular recognition. J. Mol. Recog.,
1999, 12 , 3–18. - A. Cooper, Thermodynamic analysis of biomolecular interactions. Curr. Opin. Chem. Biol., 1999, 3 ,
557–563. - T. Wiseman, S. Williston, J.F. Brandts and L.-N. Lin, Rapid measurement of binding constants and
heats of binding using a new titration calorimeter. Anal. Biochem., 1989, 179 , 131–137. - J.M. Sturtevant, Biochemical applications of differential scanning calorimetry. Ann. Rev. Phys. Chem.,
1987, 38 , 463–488. - H.W. Fisher and R.C. Williams, Electron microscopic visualization of nucleic acids and of their com-
plexes with proteins. Ann. Rev. Biochem., 1979, 48 , 649–679. - R. Thresher and J. Griffith, Electron microscopic visualization of DNA and DNA-protein complexes
as adjunct to biochemical studies. Meth. Enzymol., 1992, 211 , 481–489. - J. Frank, Single particle imaging of macromolecules by cryo-electron microscopy. Ann. Rev. Biophys.
Biomol. Struct., 2002, 31 , 303–319. - P.G. Arscott and V.A. Blomfield, Scanning tunneling microscopy of nucleic acids.Meth. Enzymol.,
1992, 211 , 490–506. - H.G. Hansma, Surface biology of DNA by atomic force microscopy. Ann. Rev. Phys. Chem., 2001, 52 ,
71–92. - H.G. Abdelhady, S. Allen, M.C. Davies, C.J. Roberts, S.J.B. Tendler and W. P.M., Direct real-time
molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I.
Nucleic Acids Res., 2003, 31 , 4001–4005. - R. Krautbauer, L.H. Pope, T.E. Schrader, S. Allen and H.E. Gaub, Discriminating drug-DNA binding
modes by single molecule force spectroscopy.FEBS Lett., 2002, 510 , 154–158. - P.F. Crain and J.A. McCloskey, Applications of mass spectrometry to the characterization of
oligonucleotides and nucleic acids. Curr. Opin. Biotechnol., 1998, 9 , 25–34. - D.J. Fu, K. Tang, A. Braun, D. Reuter, B. Darnhofer-Demar, D.P. Little, M.J. O’Donnell,
C.R. Cantor and H. Köster, Sequencing exons 5 to 8 of the p53 gene by MALDI-TOF mass
spectrometry, Nat. Biotech., 1998, 16 , 381–384. - P. Ross, L. Hall, I. Smirnov and L. Haff, High level multiplex genotyping by MALDI-TOF mass spec-
trometry. Nat. Biotech., 1998, 16 , 1347–1351. - A. Braun, D.P. Little and H. Köster, Detecting CFTR gene mutations by using primer oligo base exten-
sion and mass spectrometry. Clin. Chem., 1997, 43 , 1151–1158. - A. Braun, D.P. Little, D. Reuter, B. Muller-Mysok and H. Köster, Improved analysis of microsatellites
using mass spectrometry. Genomics, 1997, 46 , 18–23. - P. Ross and P. Belgrader, Analysis of short tandem repeat polymorphisms in human DNA by matrix-
assisted laser desorption/ionization mass spectrometry. Anal. Chem., 1997, 69 , 3966–3972. - M. Karas and F. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding
10000 Daltons. Anal. Chem., 1988, 60 , 2299–2302. - D.J. Little, T.J. Cornish, M.J. O’Donnell, A. Braun, R.J. Cotter and H. Köster, MALDI on a chip:
analysis of arrays of low-femtomole to subfemtomole quantities of synthetic oligonucleotides and
DNA diagnostic products dispensed by a piezoelectric pipet. Anal. Chem., 1997, 69 , 4540–4546.
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