Computational Methods in Systems Biology

(Ann) #1

202 B. Miraglio et al.


Definition 3 (Formula). The setFof formulason a signatureE is induc-
tively defined by:



  • any atomic formula of the formab(whereaandbcan be any element of
    E∪L) belongs toF.
    –ifφandψare elements ofF, then¬φ,φ∧ψ,φ∨ψ,φ⇒ψare also elements
    ofF.


Definition 4 (Satisfaction relation). A stateηand a formulaφ∈Fon a
signatureEbeing given, thesatisfaction relationηφis inductively defined by:


–ifφis an atom of the formab, thenηφif and only ifη(a)η(b)where
ηis the extension ofηtoE∪Lby the identity onL.
–ifφis of the formφ 1 ∧φ 2 thenη(φ 1 ∧φ 2 )if and only ifηφ 1 andηφ 2.
We proceed similarly for theother connectives.

“ηφ”isread“ηsatisfiesφ.”

We use the abbreviationa=bas a shortcut for (ab)∧(ba)andwe
proceed similarly fora<b,a>bandab.
Examples of formulas can beφ≡(I =θ), stating an excessive presence of I
orψ≡(T 4 >TPO), stating that the qualitative level of T 4 is strictly greater
than the one of TPO. The stateη 0 , previously described in Eq. 1 , satisfiesφbut
notψ.
To describe possible evolutions of the system, a set of rules of the following
form is then used:


r:A 1 +···+Am⇒Am+1+···+An when(φ) boost(ψ)

Beside its identifierr, each rule includes two sets of entitiesAi. The first one,
for alliin [1,m], constitutes the set ofconsumables, whose level may be reduced
by the application of the rule. The other set, for alliin [m+1,n], represents
the set ofproduceableswhose level may be increased by the application of the
rule. A rule also includes two modulating conditionswhen(φ)andboost(ψ)(φ
andψbeing formulas). Intuitively,φthe role of the guard of the rule andψwill
relax some restriction on the increasing of produceable levels.


Definition 5 (Biological action network).A biological action network on a
signatureE,orE-action network, is a setRof rules of the form:


r:A 1 +···+Am⇒Am+1+···+An when(φ) boost(ψ)

where:



  • ris an identifier such that there are not two rules inNwith the samer.

  • ∀i=1...n,Ai∈E.

  • {A 1 ...Am}∩{Am+1...An}=∅.

  • φandψare elements ofF.

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