Computational Methods in Systems Biology

(Ann) #1

212 B. Miraglio et al.


Table 2.TheRthyaction network.

Iintake : Ω ⇒ IB
Itransf er :IB ⇒ IT when(TSH>ε∧XI=ε)
TPOsynth : Ω ⇒ TPO when(TSH>ε) boost(TSH =θ)
TPOdestr : TPO ⇒ Ωwhen(TSH =ε∨(TPO =θ∧TSH<θ))
THsynth :IT ⇒ T3B+T4B when(TPO>ε) boost(TPO =θ)
Pitsynth :T4B ⇒ T3Pit when(D 2 >ε) boost(D 2 =θ)
Pitdestr :T3Pit ⇒ Ωwhen(T4B=ε∨D 2 =ε∨(T3Pit=θ∧D 2 <θ))
TSHsynth : Ω ⇒ TSH when(T3Pit<θ) boost(T3Pit=ε)
TSHdestr :TSH ⇒ Ωwhen(T3Pit=θ∨(TSH =θ∧T3Pit>ε))

D (^1) synth : Ω ⇒ D 1 when(XD1=ε) boost(T3B=ε)
D (^1) destr :D 1 ⇒ Ωwhen(XD1>ε∨(D 1 =θ∧T3B>ε))
D (^2) synth : Ω ⇒ D 2 when(T3B<θ∧XD2=ε) boost(T3B=ε)
D (^2) destr :D 2 ⇒ Ωwhen(T3B=θ∨XD2>ε∨(D 2 =θ∧T3B>ε))
D (^3) synth : Ω ⇒ D 3 when(T3B>ε) boost(T3B=θ)
D (^3) destr :D 3 ⇒ Ωwhen(T3B=ε∨(D 3 =θ∧T3B<θ))
Detoxsynth : Ω ⇒ Detox boost(XHep>ε)
Detoxdestr : Detox ⇒ Ωwhen(Detox =θ∧XHep=ε)
Irecycling :T4B ⇒ IB when(D 1 >ε)
THactivation :T4B ⇒ T3B when(D 1 =θ∨D 2 >ε) boost(D 2 =θ)
T (^3) destr :T3B ⇒ Ωwhen(D 3 =θ∨Detox =θ∨(T3B=θ∧D 3 >ε))
T (^4) destr :T4B ⇒ Ωwhen(D 3 =θ∨Detox =θ∨(T4B=θ∧D 3 >ε))
References



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