Multiphase Bioreactor Design

continuous

Two-stage batch – –

Continuous (chemostat) – –

Two-stage continuous – –

Perfusion with cell retention – –

with cell bleed – –

D impeller diameter (m)

H liquid height (m)

Km,app apparent oxygen saturation constant (mmol O 2 L−^1 )

kLa volumetric oxygen mass transfer coefficient (h−^1 )

N impeller rotational speed (s−^1 )

NJS minimum impeller speed for particle suspension (s−^1 )

Np power number (−)

P impeller power input (W)

Pg gassed power input (W)

qo specific oxygen consumption rate (mmol O 2 g (DW)−^1 h−^1 )

Qg aeration rate (vvm)

Qmet rate of metabolic heat generation (W)

T vessel diameter (m)

us superficial gas velocity (m s−^1 )

usr superficial gas velocity in the riser (m s−^1 )

V volume (m^3 )

w impeller blade width (m)

X biomass concentration (g DW L−^1 )

Greek Symbols
ε energy dissipation rate (W kg−^1 )

shear rate (s

−1)

ρ density (kg m−^3 )

μ (apparent) viscosity (N s m−^2 )

τ yield stress (N m−^2 )

Abbreviations

ALR air-lift reactor

DO dissolved oxygen

Multiphase bioreactor design 444