ElSohly MA, Slade D (2005) Chemical constituents of marijuana: the complex mixture of natural
cannabinoids. Life Sci 78:539– 548
Fairbairn JW (1972) The trichomes and glands ofCannabis sativaL. Bull Narc 23:29– 33
Farag S, Kayser O (2015) Cannabinoids production by hairy root cultures ofCannabis sativaL.
Am J Plant Sci 6:1874– 1884
Feeney M, Punja ZK (2003) Tissue culture andAgrobacterium-mediated transformation of hemp
(Cannabis sativaL.). In Vitro Cell Dev Biol Plant 39:578– 585
Fellermeier M, Zenk MH (1998) Prenylation of olivetolate by a hemp transferase yields
cannabigerolic acid, the precursor of tetrahydrocannabinol. FEBS Lett 427:283– 285
Fellermeier M, Eisenreich W, Bacher A, Zenk MH (2001) Biosynthesis of cannabinoids.
Incorporation experiments with^13 C-labeled glucoses. Eur J Biochem 268:1596– 1604
Flores-Sanchez IJ, Verpoorte R (2008) Secondary metabolism in cannabis. Phytochem Rev
7:615– 639
Flores-Sanchez IJ, PečJ, Fei J, Choi YH, Dušek J, Verpoorte R (2009) Elicitation studies in cell
suspension cultures ofCannabis sativaL. J Biotechnol 143:157– 168
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE (2012) Identification of olivetolic acid
cyclase fromCannabis sativareveals a unique catalytic route to plant polyketides. Proc Natl
Acad Sci U S A 109:12811– 12816
Galanie S, Thodey K, Trenchard IJ, Interrante MF, Smolke CD (2015) Complete biosymnthesis of
opioids in yeast. Science 349:1095– 1100
Gaoni Y, Mechoulam R (1964) Isolation, structure, and partial synthesis of an active constituent of
hashish. J Am Chem Soc 86:1946– 1647
Giacoppo S, Mandolino G, Galuppo M, Bramanti P, Mazzon E (2014) Cannabinoids: new
promising agents in the treatment of neurological diseases. Molecules 19:18781– 18816
Guzman M (2003) Cannabinoids: potential anticancer agents. Nat Rev Cancer 3:745– 755
Hirai MY, Sugiyama K, Sawada Y, Tohge T, Obayashi T, Suzuki A, Araki R, Sakurai N,
Suzuki H, Aoki K, Goda H, Nishizawa OI, Shibata D, Saito K (2007) Omics-based
identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate
biosynthesis. Proc Natl Acad Sci U S A 104:6478– 6483
Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998) Cannabidiol and (–)
D9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A
95:8268– 8273
Hatoum NS, Davis WM, Elsohly MA, Turner CE (1981) Cannabichromene and delta
9-tetrahydrocannabinol: interactions relative to lethality, hypothermia and hexobarbital
hypnosis. Gen Pharmacol 12:357– 362
Kajima M, Piraux M (1982) The biogenesis of cannabinoids inCannabis sativa. Phytochemistry
21:67– 69
Kim ES, Mahlberg PG (1997) Immunochemical localization of tetrahydrocannabinol (THC) in
cryofixed glandular trichomes ofCannabis(Cannabaceae). Am J Bot 84:336– 342
Kimura M, Okamoto K (1970) Distribution of tetrahydrocannabinolic acid in fresh wild cannabis.
Experientia 26:819– 820
Kushima H, Shoyama Y, Nishioka I (1980) Cannabis XII: variations of cannabinoid contents in
several strains ofCannabis sativaL. with leaf-age, season and sex. Chem Pharm Bull 28:594–
598
Kutchan TM, Dittrich H (1995) Characterization and mechanism of the berberine bridge enzyme, a
covalentlyflavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. J Biol
Chem 270:24475– 24481
Lange K, Schmid A, Julsing MK (2015)Δ^9 -tetrahydrocannabinolic acid synthase production in
Pichia pastoris enables chemical synthesis of cannbinoids. J Biotechnol 211:68– 76
Lastres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernandez-Ruiz J (2005)
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and
in vitro: relevance to Parkinson’s disease. Neurobiol Dis 19:96– 107
Leferinka NGH, Heutsb DPHM, Fraaijeb MW, van Berkela WJH (2008) The growing VAO
flavoprotein family. Arch Biochem Biophys 474:292– 301
8 Cannabinoids: Biosynthesis and Biotechnological Applications 203