Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S (2009b)
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid
biosynthetic pathway. FEBS Lett 583:2061– 2066
Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG (2005)
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and
CB2 receptor antagonist. Br J Pharmacol 146:917– 926
Turner CE, Elsohly MA (1981) Biological activity of cannabichromene, its homologs and isomers.
J Clin Pharmacol 21:283S–291S
van Bakel H, Stout JM, Cote AG, Tallon CM, Sharpe AG, Hughes TR, Page JE (2011) The draft
genome and transcriptome ofCannabis sativa. Genome Biol 12:R102
Wahby I, Caba JM, Ligero F (2013) Agrobacterium infection of hemp (Cannabis sativaL.):
establishment of hairy root cultures. J Plant Interact 8:312– 320
Weiblen GD, Wenger JP, Craft KJ, ElSohly MA, Medmedic Z, Treiber EL, Marks MD (2015)
Gene duplication and divergence affecting drug content inCannabis sativa. New Phytol
208:1241– 1250
Welle R, Grisebach H (1988) Induction of phytoalexin synthesis in soybean: enzymatic cyclization
of prenylated pterocarpans to glyceollin isomers. Arch Biochem Biophys 263:191– 198
Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan TM, Macheroux P, Gruber K (2008) A
concerted mechanism for berberine bridge enzyme. Nat Chem Biol 4:739– 741
Yamauchi T, Shoyama Y, Aramaki H, Azuma T, Nishioka I (1967) Tetrahydrocannabinolic acid, a
genuine substance of tetrahydrocannabinol. Chem Pharm Bull 15:1075– 1076
Yang X, Matsui T, Kodama T, Mori T, Zhou X, Taura F, Noguchi H, Abe I, Morita H (2016)
Structural basis for olivetolic acid formation by a polyketide cyclase fromCannabis sativa.
FEBS J 283:1088– 1106
Yazaki K, Sasaki K, Tsurumaru Y (2009) Prenylation of aromatic compounds, a key
diversification of plant secondary metabolites. Phytochemistry 70:1739– 1745
Yotoriyama M, Ito I, Takashima D, Shoyama Y, Nishioka I (1980) Plant breeding of Cannabis.
Determination of cannabinoids by high-pressure liquid chromatography. Yakugaku Zasshi
100:611– 614
Zirpel B, Stehle F, Kayser O (2015) Production of Δ^9 -tetrahydrocannabinolic acid from
cannabigerolic acid by whole cells of Pichia (Komagataella) pastoris expressionΔ^9 -
tetrahydrocannabinolic acid synthase fromCannabis sativaL. Biotechnol Lett 37:1869– 1875
206 S. Sirikantaramas and F. Taura