Cannabis sativa L. - Botany and Biotechnology

(Jacob Rumans) #1

Skrabek RQ, Galimova L, Ethans K, Perry D (2008) Nabilone for the treatment of pain in
fibromyalgia. J Pain 9:164– 173
Straiker A, Mackie K (2005) Depolarization-induced suppression of excitation in murine autaptic
hippocampal neurones. J Physiol 569:501– 517
Thomas A, Ross RA, Saha B, Mahadevan A, Razdan RK, Pertwee RG (2004) 6′′-Azidohex-2′′-
yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist. Eur J
Pharmacol 487:213– 221
Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG (2005)
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and
CB2 receptor antagonist. Br J Pharmacol 146:917– 926
Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG (2007) Cannabidiol
displays unexpectedly high potency as an antagonist of CB 1 and CB 2 receptor agonists in vitro.
Br J Pharmacol 150:613– 623
Vaccani A, Massi P, Colombo A, Rubino T, Parolaro D (2005) Cannabidiol inhibits human glioma
cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol
144:1032– 1036
Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N,
Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD,
Sharkey KA (2005) Identification and functional characterization of brainstem cannabinoid
CB 2 receptors. Science 310:329– 332
Walter L, Franklin A, Witting A, Wade C, Xie YH, Kunos G, Mackie K, Stella N (2003)
Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci
23:1398– 1405
Yamaori S, Kushihara M, Yamamoto I, Watanabe K (2010) Characterization of major
phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of
human CYP1 enzymes. Biochem Pharmacol 79:1691– 1698
Yang KH, Galadari S, Isaev D, Petroianu G, Shippenberg TS, Oz M (2010) The nonpsychoactive
cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in
Xenopus laevis oocytes. J Pharmacol Exp Ther 333:547– 554
Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (2009)
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter
(TM) assay. J Biol Chem 284:12328– 12338
Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt
ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.
Nature 400:452– 457


9 The Pharmacology and Therapeutic Potential of Plant Cannabinoids 225

Free download pdf