suppressant with a higher risk of depression and suicide. Associations of theCNR2
gene with depression, drug abuse, anorexia nervosa and schizophrenia in a human
population have also been reported (Onaivi et al. 2006 ,2008a,b), suggesting that
CB2Rs may be involved in the eCB signaling mechanisms associated with the
regulation of emotionality. More studies are therefore required to determine if
CB2R ligands have the risk of depression or suicide that has led to the withdrawal
of rimonabant from use as an appetite suppressant in the control of obesity in
Europe.
Acknowledgements We would like to thank the Dean, Dr. Wolf for student worker fund to
support the maintenance of animals in our research. ESO is supported by NIH grant DA032890.
This is also in remembrance of Dorcas Omope Dimowo who passed away during the preparation
of this chapter.
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