Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E,
Bab I, Kubisch C, de Vernejoul MC, Zimmer A (2005) The cannabinoid receptor type 2
(CNR2) gene is associated with human osteoporosis. Hum Mol Genet 14:3389– 3396
Koch M, Habazetti I, Dehghani F, Korf HW (2008) The rat pineal gland comprises an
endocannabinoid system. J Pineal Res 45:351– 360
Kong W, Li H, Tuma RF, Ganea D (2014) Selective CB2 receptor activation ameliorates EAE by
reducing TH17 differentiation and immune cell accumulation in the CNS. Cellular Immunol
287:1– 17
Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L, Callen L, Roda E, Gomez-Bautista V,
Lopez IP, Lluis C, Labandeira-Garcia JL, Franco R (2011) Expression of mRNA coding the
cannabinoid receptor 2 in the pallidal complex ofMacaca fascicularis. J Psychopharmacol
25:97– 104
Lehmann C, Burkovskiy I, Kuethe J, Zhou J, Caldwell C, Kelly MEM (2014) Inhibition of
cannabinoid 2 receptor in CNS-injury induced immunodeficiency syndrome. Med Hypothesis
82:736– 739
Liu Q-R, Pan C-H, Hishimoto A, Li C-Y, Xi Z-X, Llorente Berzal A, Viveros MA, Ishiguro H,
Arinami T, Onaivi ES, Uhl GR (2009) Species differences in cannabinoid receptor 2 (CNR2
gene): identification of novel human and rodent CB2 isoforms, differential tissue expression,
and regulation by cannabinoid receptor ligands. Genes Brain Behav 8:519– 530
Lovinger DM (2008) Presynaptic modulation by endocannabinoids. Handb Exp Pharmacol
184:435– 477
Malfitano AM, Basu S, Bifulco M, Dittel BN (2014) What we know and do not know about the
cannabinoid receptor 2. Semin Immunol 26:369– 379
Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG,
Gutiérrez SO, van der Stelt M, Lopez-Rodriguez ML, Casanova E, Schutz G,
Zieglgansberger W, Di Marzo V, Behl C, Lutz B (2003) CB1 cannabinoid receptors and
on-demand defense against excitotoxicity. Science 302:84– 88
Minocci D, Massei J, Martino A, Milianti M, Piz L, Di Bello D, Sbrana A, Martinotti E,
Rossi AM, Nieri P (2011) Genetic association between bipolar disorder and 524A > C
(Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor. J Affect
Disord 134:427– 430
Monory K, Massa F, Egertova M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W,
Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave K-A, During M, Klugmann M,
Woflel B, Dodt H-U, Zieglgansberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G,
Lutz B (2006) The endocannabinoid system controls key epileptogenic circuits in the
hippocampus. Neuron 51:455– 466
Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for
cannabinoids. Nature 365:61– 65
Nagarkatti P, Pandey R, Rieder SA, Hedge VL, Nagarkatti M (2010) Cannabinoids as novel
anti-inflammatory drugs. Future Med Chem 1:1333– 1349
Navarrete F, Pérez-Ortiz JM, Manzanares J (2012) Cannabinoid CB2 receptor-mediated regulation
of impulsivelike behaviour in DBA/2 mice. Br J Pharmacol 165:260– 273
Navarrete F, Rodríguez-Arias M, Martín-García E, Navarro D, García-Gutiérrez MS, Aguilar MA,
Aracil-Fernández A, Berbel P, Miñarro J, Maldonado R, Manzanares J (2013) Role of CB2
cannabinoid receptors in the rewarding, reinforcing and physical effects of nicotine.
Neuropsychopharmacology 38:2515– 2524
Ndong C, O’Donnell D, Ahmad S, Groblewski T (2011) Cloning and pharmacological
characterization of the dog cannabinoid CB2 receptor. Eur J Pharmacol 669:24– 31
Nunez E, Benito C, Pazos MR, Barbachano A, Fajardo O, Gonzalez S, Tolon RM, Romero J
(2004) Cannabinoid CB2 receptors are expressed by perivascular microglia cells in the human
brain: an immunohistochemical study. Synapse 53:208– 213
Onaivi ES (2006) Preface. In: Onaivi ES (ed) Marijuana and cannabinoid research, methods and
protocols. Humana Press, Totowa, pp vii
10 Cannabinoid CB2 Receptor Mechanism ofCannabis sativaL. 245